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2zs6

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{{Seed}}
 
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[[Image:2zs6.jpg|left|200px]]
 
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==HA3 subcomponent of botulinum type C progenitor toxin==
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The line below this paragraph, containing "STRUCTURE_2zs6", creates the "Structure Box" on the page.
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<StructureSection load='2zs6' size='340' side='right'caption='[[2zs6]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2zs6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2z5a 2z5a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZS6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZS6 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zs6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zs6 OCA], [https://pdbe.org/2zs6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zs6 RCSB], [https://www.ebi.ac.uk/pdbsum/2zs6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zs6 ProSAT]</span></td></tr>
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{{STRUCTURE_2zs6| PDB=2zs6 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HA70C_CBCP HA70C_CBCP] The hemagglutinin (HA) component of the progenitor toxin protects the structural integrity of botulinum neurotoxin; may increase internalization of the neurotoxin into the bloodstream of the host (PubMed:9421908). The HA component is involved in binding to the upper small intestine through interactions with glycolipids and glycoproteins containing sialic acid moieties (Probable). Whole protein and the HA-53 chain (but not the HA-22-23 chain) bind to bovine mucin; if the mucin is pretreated with neuraminidase (removes the terminal sialic acid of glycoconjugates) mucin binding is decreased (PubMed:19071137). Has higher affinity for alpha-2,3-sialylated oligosaccharides than alpha-2-6 sialylated oligosaccharides (PubMed:22684008).<ref>PMID:19071137</ref> <ref>PMID:22684008</ref> <ref>PMID:9421908</ref> <ref>PMID:9421908</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zs/2zs6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zs6 ConSurf].
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<div style="clear:both"></div>
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===HA3 subcomponent of botulinum type C progenitor toxin===
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==See Also==
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*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]
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== References ==
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 18178224 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_18178224}}
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==About this Structure==
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2ZS6 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2z5a 2z5a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZS6 OCA].
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==Reference==
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Sugar-binding sites of the HA1 subcomponent of Clostridium botulinum type C progenitor toxin., Nakamura T, Tonozuka T, Ide A, Yuzawa T, Oguma K, Nishikawa A, J Mol Biol. 2008 Feb 22;376(3):854-67. Epub 2007 Dec 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18178224 18178224]
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Binding properties of Clostridium botulinum type C progenitor toxin to mucins., Nakamura T, Takada N, Tonozuka T, Sakano Y, Oguma K, Nishikawa A, Biochim Biophys Acta. 2007 Apr;1770(4):551-5. Epub 2006 Nov 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17196748 17196748]
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[[Category: Clostridium botulinum]]
[[Category: Clostridium botulinum]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Kotani, M.]]
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[[Category: Kotani M]]
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[[Category: Nakamura, T.]]
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[[Category: Nakamura T]]
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[[Category: Nishikawa, A.]]
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[[Category: Nishikawa A]]
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[[Category: Oguma, K.]]
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[[Category: Oguma K]]
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[[Category: Tonozuka, T.]]
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[[Category: Tonozuka T]]
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[[Category: Botulinum toxin]]
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[[Category: Hemagglutinin]]
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[[Category: Lectin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 17 14:03:38 2008''
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Current revision

HA3 subcomponent of botulinum type C progenitor toxin

PDB ID 2zs6

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