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3a1a

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[[Image:3a1a.png|left|200px]]
 
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{{STRUCTURE_3a1a| PDB=3a1a | SCENE= }}
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==Crystal Structure of the DNMT3A ADD domain==
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<StructureSection load='3a1a' size='340' side='right'caption='[[3a1a]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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===Crystal Structure of the DNMT3A ADD domain===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3a1a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A1A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3A1A FirstGlance]. <br>
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{{ABSTRACT_PUBMED_19834512}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3a1a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a1a OCA], [https://pdbe.org/3a1a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3a1a RCSB], [https://www.ebi.ac.uk/pdbsum/3a1a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3a1a ProSAT]</span></td></tr>
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[[3a1a]] is a 1 chain structure of [[DNA methyltransferase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A1A OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DNM3A_HUMAN DNM3A_HUMAN] Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZNF238. Can actively repress transcription through the recruitment of HDAC activity (By similarity).<ref>PMID:16357870</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a1/3a1a_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3a1a ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[DNA methyltransferase|DNA methyltransferase]]
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*[[DNA methyltransferase 3D structures|DNA methyltransferase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:019834512</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arita, K.]]
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[[Category: Large Structures]]
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[[Category: Ariyoshi, M.]]
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[[Category: Arita K]]
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[[Category: Otani, J.]]
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[[Category: Ariyoshi M]]
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[[Category: Shirakawa, M.]]
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[[Category: Otani J]]
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[[Category: Alternative promoter usage]]
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[[Category: Shirakawa M]]
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[[Category: Dna-binding]]
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[[Category: Metal-binding]]
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[[Category: Methyltransferase]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: S-adenosyl-l-methionine]]
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[[Category: Transferase]]
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[[Category: Zinc-finger]]
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Current revision

Crystal Structure of the DNMT3A ADD domain

PDB ID 3a1a

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