3a1f

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[[Image:3a1f.png|left|200px]]
 
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{{STRUCTURE_3a1f| PDB=3a1f | SCENE= }}
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==The crystal structure of NADPH binding domain of gp91(phox)==
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<StructureSection load='3a1f' size='340' side='right'caption='[[3a1f]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3a1f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A1F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3A1F FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3a1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a1f OCA], [https://pdbe.org/3a1f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3a1f RCSB], [https://www.ebi.ac.uk/pdbsum/3a1f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3a1f ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CY24B_HUMAN CY24B_HUMAN] Defects in CYBB are a cause of granulomatous disease,chronic, X-linked (CGD) [MIM:[https://omim.org/entry/306400 306400]. A disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections.<ref>PMID:12139950</ref> <ref>PMID:2556453</ref> <ref>PMID:1710153</ref> <ref>PMID:8101486</ref> <ref>PMID:7927345</ref> <ref>PMID:8182143</ref> <ref>PMID:8916969</ref> <ref>PMID:9111587</ref> <ref>PMID:9585602</ref> <ref>PMID:9856476</ref> <ref>PMID:9794433</ref> <ref>PMID:9667376</ref> <ref>PMID:10089913</ref> <ref>PMID:9888386</ref> <ref>PMID:10914676</ref> <ref>PMID:11462241</ref> <ref>PMID:11997083</ref> <ref>PMID:15338276</ref> <ref>PMID:18773283</ref> <ref>PMID:22125116</ref> Defects in CYBB are a cause of mycobacteriosis atypical X-linked type 2 (AMCBX2) [MIM:[https://omim.org/entry/300645 300645]. A rare condition characterized by predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections.<ref>PMID:21278736</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/CY24B_HUMAN CY24B_HUMAN] Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a1/3a1f_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3a1f ConSurf].
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<div style="clear:both"></div>
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===The crystal structure of NADPH binding domain of gp91(phox)===
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==See Also==
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*[[NADPH oxidase 3D structures|NADPH oxidase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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[[3a1f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A1F OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Honbou, K.]]
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[[Category: Large Structures]]
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[[Category: Nadph binding domain]]
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[[Category: Honbou K]]
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[[Category: Oxidoreductase]]
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Current revision

The crystal structure of NADPH binding domain of gp91(phox)

PDB ID 3a1f

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