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3ady

From Proteopedia

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<StructureSection load='3ady' size='340' side='right'caption='[[3ady]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='3ady' size='340' side='right'caption='[[3ady]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3ady]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Legph Legph]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ADY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ADY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3ady]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Legionella_pneumophila_subsp._pneumophila_str._Philadelphia_1 Legionella pneumophila subsp. pneumophila str. Philadelphia 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ADY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ADY FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dotD, lpg2674 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272624 LEGPH])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ady FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ady OCA], [https://pdbe.org/3ady PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ady RCSB], [https://www.ebi.ac.uk/pdbsum/3ady PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ady ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ady FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ady OCA], [https://pdbe.org/3ady PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ady RCSB], [https://www.ebi.ac.uk/pdbsum/3ady PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ady ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q5ZS45_LEGPH Q5ZS45_LEGPH]
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The Dot/Icm type IVB secretion system (T4BSS) is a pivotal determinant of Legionella pneumophila pathogenesis. L. pneumophila translocate more than 100 effector proteins into host cytoplasm using Dot/Icm T4BSS, modulating host cellular functions to establish a replicative niche within host cells. The T4BSS core complex spanning the inner and outer membranes is thought to be made up of at least five proteins: DotC, DotD, DotF, DotG and DotH. DotH is the outer membrane protein; its targeting depends on lipoproteins DotC and DotD. However, the core complex structure and assembly mechanism are still unknown. Here, we report the crystal structure of DotD at 2.0 A resolution. The structure of DotD is distinct from that of VirB7, the outer membrane lipoprotein of the type IVA secretion system. In contrast, the C-terminal domain of DotD is remarkably similar to the N-terminal subdomain of secretins, the integral outer membrane proteins that form substrate conduits for the type II and the type III secretion systems (T2SS and T3SS). A short beta-segment in the otherwise disordered N-terminal region, located on the hydrophobic cleft of the C-terminal domain, is essential for outer membrane targeting of DotH and Dot/Icm T4BSS core complex formation. These findings uncover an intriguing link between T4BSS and T2SS/T3SS.
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Crystal structure of Legionella DotD: insights into the relationship between type IVB and type II/III secretion systems.,Nakano N, Kubori T, Kinoshita M, Imada K, Nagai H PLoS Pathog. 2010 Oct 7;6(10). pii: e1001129. PMID:20949065<ref>PMID:20949065</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3ady" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Legph]]
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[[Category: Legionella pneumophila subsp. pneumophila str. Philadelphia 1]]
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[[Category: Imada, K]]
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[[Category: Imada K]]
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[[Category: Kinoshita, M]]
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[[Category: Kinoshita M]]
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[[Category: Kubori, T]]
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[[Category: Kubori T]]
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[[Category: Nagai, H]]
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[[Category: Nagai H]]
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[[Category: Nakano, N]]
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[[Category: Nakano N]]
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[[Category: Mth1598-like]]
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[[Category: Proton transport]]
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Current revision

Crystal structure of DotD from Legionella

PDB ID 3ady

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