This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3akj
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3akj is ON HOLD Authors: Do Jin, Kim, Se Won, Suh Description: Crystal structure of A Helicobacter pylori proinflammatory kinase CtkA ''Page seede...) |
|||
| (9 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of A Helicobacter pylori proinflammatory kinase CtkA== | |
| - | + | <StructureSection load='3akj' size='340' side='right'caption='[[3akj]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3akj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori_J99 Helicobacter pylori J99]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AKJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AKJ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3akj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3akj OCA], [https://pdbe.org/3akj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3akj RCSB], [https://www.ebi.ac.uk/pdbsum/3akj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3akj ProSAT]</span></td></tr> | |
| - | '' | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CTKA_HELPJ CTKA_HELPJ] Virulence factor acting as a pro-inflammatory protein that induces the secretion of the pro-inflammatory cytokines TNF-alpha (tumor necrosis factor-alpha) and IL-8 (interleukin-8) from human macrophages, as well as enhanced translocation of the transcription factor NF-kappa-B complex in macrophages. Is a kinase capable of autophosphorylating itself at a threonine residue near the N-terminus. Also leads to enhanced phosphorylation of the NF-kappa-B p65 subunit (RELA) at 'Ser-276' in human epithelial cancer cells; its kinase activity is required for this enhanced phosphorylation that up-regulates NF-kappa-B activity, but it does not directly phosphorylate this protein. Thus, the kinase activity of CtkA may play an important role in the induction of host inflammatory responses during H.pylori infection.<ref>PMID:17993522</ref> <ref>PMID:21098302</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Helicobacter pylori J99]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Kim DJ]] | ||
| + | [[Category: Suh SW]] | ||
Current revision
Crystal structure of A Helicobacter pylori proinflammatory kinase CtkA
| |||||||||||
