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3al5
From Proteopedia
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| - | [[Image:3al5.png|left|200px]] | ||
| - | + | ==Crystal structure of Human TYW5== | |
| - | + | <StructureSection load='3al5' size='340' side='right'caption='[[3al5]], [[Resolution|resolution]] 2.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3al5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AL5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AL5 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.503Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3al5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3al5 OCA], [https://pdbe.org/3al5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3al5 RCSB], [https://www.ebi.ac.uk/pdbsum/3al5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3al5 ProSAT]</span></td></tr> |
| - | [[3al5]] is a 4 chain structure with sequence from [ | + | </table> |
| - | + | == Function == | |
| - | == | + | [https://www.uniprot.org/uniprot/TYW5_HUMAN TYW5_HUMAN] tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes.<ref>PMID:20739293</ref> |
| - | < | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Araiso | + | [[Category: Large Structures]] |
| - | [[Category: Ishitani | + | [[Category: Araiso Y]] |
| - | [[Category: Kato | + | [[Category: Ishitani R]] |
| - | [[Category: Nureki | + | [[Category: Kato M]] |
| - | + | [[Category: Nureki O]] | |
| - | + | ||
Current revision
Crystal structure of Human TYW5
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