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3alr

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==Crystal structure of Nanos==
==Crystal structure of Nanos==
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<StructureSection load='3alr' size='340' side='right' caption='[[3alr]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='3alr' size='340' side='right'caption='[[3alr]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3alr]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ALR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ALR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3alr]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ALR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ALR FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">nanos ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Danio rerio])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3alr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3alr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3alr RCSB], [http://www.ebi.ac.uk/pdbsum/3alr PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3alr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3alr OCA], [https://pdbe.org/3alr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3alr RCSB], [https://www.ebi.ac.uk/pdbsum/3alr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3alr ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q4QRE8_DANRE Q4QRE8_DANRE]
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Nanos is an RNA-binding protein that is involved in the development and maintenance of germ cells. In combination with Pumilio, Nanos binds to the 3' untranslated region of a messenger RNA and represses its translation. Nanos has two conserved Cys-Cys-His-Cys zinc-finger motifs that are indispensable for its function. In this study, we have determined the crystal structure of the zinc-finger domain of zebrafish Nanos, for the first time revealing that Nanos adopts a novel zinc-finger structure. In addition, Nanos has a conserved basic surface that is directly involved in RNA binding. Our results provide the structural basis for further studies to clarify Nanos function.
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Crystal structure of zinc-finger domain of Nanos and its functional implications.,Hashimoto H, Hara K, Hishiki A, Kawaguchi S, Shichijo N, Nakamura K, Unzai S, Tamaru Y, Shimizu T, Sato M EMBO Rep. 2010 Nov;11(11):848-53. Epub 2010 Oct 15. PMID:20948543<ref>PMID:20948543</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Danio rerio]]
[[Category: Danio rerio]]
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[[Category: Hara, K]]
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[[Category: Large Structures]]
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[[Category: Hashimoto, H]]
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[[Category: Hara K]]
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[[Category: Hishiki, A]]
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[[Category: Hashimoto H]]
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[[Category: Kawaguchi, S]]
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[[Category: Hishiki A]]
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[[Category: Nakamura, K]]
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[[Category: Kawaguchi S]]
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[[Category: Sato, M]]
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[[Category: Nakamura K]]
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[[Category: Shichijo, N]]
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[[Category: Sato M]]
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[[Category: Shimizu, T]]
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[[Category: Shichijo N]]
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[[Category: Tamaru, Y]]
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[[Category: Shimizu T]]
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[[Category: Unzai, S]]
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[[Category: Tamaru Y]]
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[[Category: 3'-utr]]
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[[Category: Unzai S]]
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[[Category: Metal binding protein]]
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[[Category: Rna]]
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[[Category: Translational repression]]
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[[Category: Zinc-finger]]
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Current revision

Crystal structure of Nanos

PDB ID 3alr

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