3b0f

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[[Image:3b0f.jpg|left|200px]]
 
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==Crystal structure of the UBA domain of p62 and its interaction with ubiquitin==
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The line below this paragraph, containing "STRUCTURE_3b0f", creates the "Structure Box" on the page.
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<StructureSection load='3b0f' size='340' side='right'caption='[[3b0f]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3b0f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B0F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B0F FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3b0f| PDB=3b0f | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b0f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b0f OCA], [https://pdbe.org/3b0f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b0f RCSB], [https://www.ebi.ac.uk/pdbsum/3b0f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b0f ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SQSTM_MOUSE SQSTM_MOUSE] Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures). Links ALIS to the autophagic machinery via direct interaction with MAP1 LC3 family members. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Adapter that mediates the interaction between TRAF6 and CYLD.<ref>PMID:14960283</ref> <ref>PMID:18382763</ref>
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===Crystal structure of the UBA domain of p62 and its interaction with ubiquitin===
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==See Also==
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*[[Sequestosome|Sequestosome]]
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== References ==
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==About this Structure==
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<references/>
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[[3b0f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B0F OCA].
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Arita, K.]]
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[[Category: Arita K]]
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[[Category: Hasegawa, J.]]
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[[Category: Hasegawa J]]
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[[Category: Isogai, S.]]
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[[Category: Isogai S]]
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[[Category: Komatsu, M.]]
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[[Category: Komatsu M]]
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[[Category: Morimoto, D.]]
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[[Category: Morimoto D]]
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[[Category: Shirakawa, M.]]
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[[Category: Shirakawa M]]
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[[Category: Sou, Y.]]
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[[Category: Sou Y]]
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[[Category: Tanaka, K.]]
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[[Category: Tanaka K]]
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[[Category: Tenno, T.]]
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[[Category: Tenno T]]
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[[Category: Tochio, H.]]
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[[Category: Tochio H]]
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[[Category: Unzai, S.]]
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[[Category: Unzai S]]
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[[Category: Autophagy]]
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[[Category: Protein binding]]
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[[Category: Ubiquitin]]
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Current revision

Crystal structure of the UBA domain of p62 and its interaction with ubiquitin

PDB ID 3b0f

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