3b0f

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (14:03, 13 March 2024) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
==Crystal structure of the UBA domain of p62 and its interaction with ubiquitin==
==Crystal structure of the UBA domain of p62 and its interaction with ubiquitin==
-
<StructureSection load='3b0f' size='340' side='right' caption='[[3b0f]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
+
<StructureSection load='3b0f' size='340' side='right'caption='[[3b0f]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3b0f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B0F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3B0F FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3b0f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B0F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B0F FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2rru|2rru]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Sqstm1, A170, STAP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b0f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b0f OCA], [https://pdbe.org/3b0f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b0f RCSB], [https://www.ebi.ac.uk/pdbsum/3b0f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b0f ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3b0f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b0f OCA], [http://pdbe.org/3b0f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3b0f RCSB], [http://www.ebi.ac.uk/pdbsum/3b0f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3b0f ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/SQSTM_MOUSE SQSTM_MOUSE]] Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures). Links ALIS to the autophagic machinery via direct interaction with MAP1 LC3 family members. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Adapter that mediates the interaction between TRAF6 and CYLD.<ref>PMID:14960283</ref> <ref>PMID:18382763</ref>
+
[https://www.uniprot.org/uniprot/SQSTM_MOUSE SQSTM_MOUSE] Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures). Links ALIS to the autophagic machinery via direct interaction with MAP1 LC3 family members. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Adapter that mediates the interaction between TRAF6 and CYLD.<ref>PMID:14960283</ref> <ref>PMID:18382763</ref>
==See Also==
==See Also==
Line 18: Line 17:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Lk3 transgenic mice]]
+
[[Category: Large Structures]]
-
[[Category: Arita, K]]
+
[[Category: Mus musculus]]
-
[[Category: Hasegawa, J]]
+
[[Category: Arita K]]
-
[[Category: Isogai, S]]
+
[[Category: Hasegawa J]]
-
[[Category: Komatsu, M]]
+
[[Category: Isogai S]]
-
[[Category: Morimoto, D]]
+
[[Category: Komatsu M]]
-
[[Category: Shirakawa, M]]
+
[[Category: Morimoto D]]
-
[[Category: Sou, Y]]
+
[[Category: Shirakawa M]]
-
[[Category: Tanaka, K]]
+
[[Category: Sou Y]]
-
[[Category: Tenno, T]]
+
[[Category: Tanaka K]]
-
[[Category: Tochio, H]]
+
[[Category: Tenno T]]
-
[[Category: Unzai, S]]
+
[[Category: Tochio H]]
-
[[Category: Autophagy]]
+
[[Category: Unzai S]]
-
[[Category: Protein binding]]
+
-
[[Category: Ubiquitin]]
+

Current revision

Crystal structure of the UBA domain of p62 and its interaction with ubiquitin

PDB ID 3b0f

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3b0f"
Personal tools