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3bd9

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(New page: 200px<br /><applet load="3bd9" size="350" color="white" frame="true" align="right" spinBox="true" caption="3bd9, resolution 2.30&Aring;" /> '''human 3-O-sulfotrans...)
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[[Image:3bd9.jpg|left|200px]]<br /><applet load="3bd9" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="3bd9, resolution 2.30&Aring;" />
 
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'''human 3-O-sulfotransferase isoform 5 with bound PAP'''<br />
 
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==About this Structure==
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==human 3-O-sulfotransferase isoform 5 with bound PAP==
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3BD9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=A3P:'>A3P</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/[Heparan_sulfate]-glucosamine_3-sulfotransferase_1 [Heparan sulfate]-glucosamine 3-sulfotransferase 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.2.23 2.8.2.23] Known structural/functional Site: <scene name='pdbsite=AC1:A3p Binding Site For Residue A 347'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BD9 OCA].
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<StructureSection load='3bd9' size='340' side='right'caption='[[3bd9]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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[[Category: Homo sapiens]]
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== Structural highlights ==
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[[Category: Single protein]]
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<table><tr><td colspan='2'>[[3bd9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BD9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BD9 FirstGlance]. <br>
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[[Category: [Heparan sulfate]-glucosamine 3-sulfotransferase 1]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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[[Category: Liu, J.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene></td></tr>
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[[Category: Moon, A.F.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bd9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bd9 OCA], [https://pdbe.org/3bd9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bd9 RCSB], [https://www.ebi.ac.uk/pdbsum/3bd9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bd9 ProSAT]</span></td></tr>
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[[Category: Pedersen, L.C.]]
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</table>
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[[Category: Song, D.]]
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== Function ==
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[[Category: Xu, D.]]
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[https://www.uniprot.org/uniprot/HS3S5_HUMAN HS3S5_HUMAN] Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site. Also generates GlcUA-GlcNS or IdoUA-GlcNS and IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry.<ref>PMID:12138164</ref>
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[[Category: A3P]]
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== Evolutionary Conservation ==
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[[Category: 3-o-sulfotransferase]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: glycoprotein]]
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Check<jmol>
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[[Category: golgi apparatus]]
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<jmolCheckbox>
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[[Category: heparan sulfate]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bd/3bd9_consurf.spt"</scriptWhenChecked>
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[[Category: heparan sulfate biosynthesis]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: membrane]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: signal-anchor]]
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</jmolCheckbox>
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[[Category: substrate specificity]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bd9 ConSurf].
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[[Category: transmembrane]]
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<div style="clear:both"></div>
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jan 31 11:03:19 2008''
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==See Also==
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*[[Sulfotransferase 3D structures|Sulfotransferase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Liu J]]
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[[Category: Moon AF]]
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[[Category: Pedersen LC]]
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[[Category: Song D]]
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[[Category: Xu D]]

Current revision

human 3-O-sulfotransferase isoform 5 with bound PAP

PDB ID 3bd9

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