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3c0i

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{{Seed}}
 
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[[Image:3c0i.png|left|200px]]
 
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==CASK CaM-Kinase Domain- 3'-AMP complex, P212121 form==
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The line below this paragraph, containing "STRUCTURE_3c0i", creates the "Structure Box" on the page.
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<StructureSection load='3c0i' size='340' side='right'caption='[[3c0i]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3c0i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C0I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C0I FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3AM:[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-4-HYDROXY-2-(HYDROXYMETHYL)OXOLAN-3-YL]+DIHYDROGEN+PHOSPHATE'>3AM</scene></td></tr>
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{{STRUCTURE_3c0i| PDB=3c0i | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c0i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c0i OCA], [https://pdbe.org/3c0i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c0i RCSB], [https://www.ebi.ac.uk/pdbsum/3c0i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c0i ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CSKP_HUMAN CSKP_HUMAN] Defects in CASK are the cause of mental retardation and microcephaly with pontine and cerebellar hypoplasia (MICPCH) [MIM:[https://omim.org/entry/300749 300749]. A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Patients with mental retardation X-linked CASK-related can manifest a severe phenotype consisting of severe intellectual deficit, congenital or postnatal microcephaly, disproportionate brainstem and cerebellar hypoplasia. A milder phenotype consists of mental retardation alone or associated with nystagmus.<ref>PMID:19165920</ref> Defects in CASK are the cause of FG syndrome type 4 (FGS4) [MIM:[https://omim.org/entry/300422 300422]. FG syndrome (FGS) is an X-linked disorder characterized by mental retardation, relative macrocephaly, hypotonia and constipation.<ref>PMID:19200522</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/CSKP_HUMAN CSKP_HUMAN] Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TRB1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c0/3c0i_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3c0i ConSurf].
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<div style="clear:both"></div>
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===CASK CaM-Kinase Domain- 3'-AMP complex, P212121 form===
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==See Also==
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*[[Calcium/calmodulin dependent protein kinase 3D structures|Calcium/calmodulin dependent protein kinase 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_18423203}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 18423203 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_18423203}}
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==About this Structure==
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3C0I is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C0I OCA].
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==Reference==
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CASK Functions as a Mg2+-independent neurexin kinase., Mukherjee K, Sharma M, Urlaub H, Bourenkov GP, Jahn R, Sudhof TC, Wahl MC, Cell. 2008 Apr 18;133(2):328-39. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18423203 18423203]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Wahl MC]]
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[[Category: Wahl, M C.]]
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[[Category: Alternative splicing]]
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[[Category: Atp-binding]]
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[[Category: Ca2+/calmodulin dependent protein kinase]]
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[[Category: Calmodulin-binding]]
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[[Category: Cask]]
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[[Category: Cytoplasm]]
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[[Category: Magnesium]]
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[[Category: Maguk]]
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[[Category: Membrane-associated guanylate kinase]]
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[[Category: Metal-binding]]
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[[Category: Mg2+]]
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[[Category: Neurexin]]
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[[Category: Nucleotide-binding]]
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[[Category: Nucleus]]
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[[Category: Pseudokinase]]
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[[Category: Serine/threonine-protein kinase]]
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[[Category: Sh3 domain]]
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[[Category: Synaptic plasticity]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 01:41:02 2008''
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Current revision

CASK CaM-Kinase Domain- 3'-AMP complex, P212121 form

PDB ID 3c0i

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