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3kyc

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[[Image:3kyc.png|left|200px]]
 
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{{STRUCTURE_3kyc| PDB=3kyc | SCENE= }}
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==Human SUMO E1 complex with a SUMO1-AMP mimic==
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<StructureSection load='3kyc' size='340' side='right'caption='[[3kyc]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
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===Human SUMO E1 complex with a SUMO1-AMP mimic===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3kyc]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KYC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KYC FirstGlance]. <br>
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{{ABSTRACT_PUBMED_20164921}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JZU:5-DEOXY-5-(SULFAMOYLAMINO)ADENOSINE'>JZU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kyc OCA], [https://pdbe.org/3kyc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kyc RCSB], [https://www.ebi.ac.uk/pdbsum/3kyc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kyc ProSAT]</span></td></tr>
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[[3kyc]] is a 3 chain structure of [[Human SUMO E1 complex]] and [[SUMO]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KYC OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SAE1_HUMAN SAE1_HUMAN] The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.<ref>PMID:9920803</ref> <ref>PMID:10217437</ref> <ref>PMID:10187858</ref> <ref>PMID:11481243</ref> <ref>PMID:11451954</ref> <ref>PMID:15660128</ref> <ref>PMID:20164921</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ky/3kyc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kyc ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[Human SUMO E1 complex|Human SUMO E1 complex]]
*[[Human SUMO E1 complex|Human SUMO E1 complex]]
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*[[Human SUMO E1 complex with a SUMO1-AMP mimic|Human SUMO E1 complex with a SUMO1-AMP mimic]]
 
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*[[Human SUMO E1~SUMO1-AMP tetrahedral intermediate mimic|Human SUMO E1~SUMO1-AMP tetrahedral intermediate mimic]]
 
*[[SUMO|SUMO]]
*[[SUMO|SUMO]]
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*[[SUMO 3D Structures|SUMO 3D Structures]]
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==Reference==
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*[[3D structures of Ubiquitin activating enzyme|3D structures of Ubiquitin activating enzyme]]
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<ref group="xtra">PMID:020164921</ref><references group="xtra"/>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Lima, C D.]]
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[[Category: Large Structures]]
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[[Category: Acyl-adenylate intermediate]]
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[[Category: Lima CD]]
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[[Category: Adenylation]]
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[[Category: Atp-binding]]
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[[Category: E1]]
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[[Category: Inhibitor]]
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[[Category: Isopeptide bond]]
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[[Category: Ligase]]
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[[Category: Membrane]]
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[[Category: Nucleotide-binding]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Sumo]]
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[[Category: Thioester]]
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[[Category: Ubiquitin]]
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[[Category: Ubl conjugation pathway]]
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Current revision

Human SUMO E1 complex with a SUMO1-AMP mimic

PDB ID 3kyc

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