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5uvn

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==Structure of E. coli MCE protein PqiB, periplasmic domain==
==Structure of E. coli MCE protein PqiB, periplasmic domain==
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<StructureSection load='5uvn' size='340' side='right' caption='[[5uvn]], [[Resolution|resolution]] 3.96&Aring;' scene=''>
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<SX load='5uvn' size='340' side='right' viewer='molstar' caption='[[5uvn]], [[Resolution|resolution]] 3.96&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5uvn]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UVN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UVN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5uvn]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UVN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UVN FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.96&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5uw2|5uw2]], [[5uw8|5uw8]], [[5uwa|5uwa]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5uvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uvn OCA], [https://pdbe.org/5uvn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5uvn RCSB], [https://www.ebi.ac.uk/pdbsum/5uvn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5uvn ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pqiB, pqi5B, b0951, JW0934 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uvn OCA], [http://pdbe.org/5uvn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uvn RCSB], [http://www.ebi.ac.uk/pdbsum/5uvn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uvn ProSAT]</span></td></tr>
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</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/PQIB_ECOLI PQIB_ECOLI]
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How phospholipids are trafficked between the bacterial inner and outer membranes through the hydrophilic space of the periplasm is not known. We report that members of the mammalian cell entry (MCE) protein family form hexameric assemblies with a central channel capable of mediating lipid transport. The E. coli MCE protein, MlaD, forms a ring associated with an ABC transporter complex in the inner membrane. A soluble lipid-binding protein, MlaC, ferries lipids between MlaD and an outer membrane protein complex. In contrast, EM structures of two other E. coli MCE proteins show that YebT forms an elongated tube consisting of seven stacked MCE rings, and PqiB adopts a syringe-like architecture. Both YebT and PqiB create channels of sufficient length to span the periplasmic space. This work reveals diverse architectures of highly conserved protein-based channels implicated in the transport of lipids between the membranes of bacteria and some eukaryotic organelles.
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Architectures of Lipid Transport Systems for the Bacterial Outer Membrane.,Ekiert DC, Bhabha G, Isom GL, Greenan G, Ovchinnikov S, Henderson IR, Cox JS, Vale RD Cell. 2017 Apr 6;169(2):273-285.e17. doi: 10.1016/j.cell.2017.03.019. PMID:28388411<ref>PMID:28388411</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5uvn" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
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</StructureSection>
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</SX>
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[[Category: Ecoli]]
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[[Category: Escherichia coli K-12]]
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[[Category: Bhabha, G]]
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[[Category: Large Structures]]
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[[Category: Ekiert, D C]]
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[[Category: Bhabha G]]
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[[Category: Bacterial lipid transport]]
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[[Category: Ekiert DC]]
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[[Category: Mce protein]]
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[[Category: Transport protein]]
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Current revision

Structure of E. coli MCE protein PqiB, periplasmic domain

5uvn, resolution 3.96Å

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OCA

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