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5w8s

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==Lipid A Disaccharide Synthase (LpxB)-7 solubilizing mutations==
==Lipid A Disaccharide Synthase (LpxB)-7 solubilizing mutations==
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<StructureSection load='5w8s' size='340' side='right' caption='[[5w8s]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='5w8s' size='340' side='right'caption='[[5w8s]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5w8s]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W8S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5W8S FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5w8s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_BL21(DE3) Escherichia coli BL21(DE3)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W8S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5W8S FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LI:LITHIUM+ION'>LI</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5w8x|5w8x]], [[5w8n|5w8n]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LI:LITHIUM+ION'>LI</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lipid-A-disaccharide_synthase Lipid-A-disaccharide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.182 2.4.1.182] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5w8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w8s OCA], [https://pdbe.org/5w8s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5w8s RCSB], [https://www.ebi.ac.uk/pdbsum/5w8s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5w8s ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5w8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w8s OCA], [http://pdbe.org/5w8s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5w8s RCSB], [http://www.ebi.ac.uk/pdbsum/5w8s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5w8s ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/A0A140NAT1_ECOBD A0A140NAT1_ECOBD]] Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.[HAMAP-Rule:MF_00392][SAAS:SAAS00702254]
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[https://www.uniprot.org/uniprot/LPXB_ECOLI LPXB_ECOLI] Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lipid-A-disaccharide synthase]]
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[[Category: Large Structures]]
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[[Category: Aihara, H]]
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[[Category: Aihara H]]
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[[Category: Bohl, T E]]
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[[Category: Bohl TE]]
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[[Category: Lee, J K]]
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[[Category: Lee JK]]
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[[Category: Shi, K]]
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[[Category: Shi K]]
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[[Category: C-terminal swap]]
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[[Category: Dimer]]
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[[Category: Glycosyltransferase b]]
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[[Category: Lipid a disaccharide synthase]]
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[[Category: Lipid a synthesis pathway]]
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[[Category: Lipiopolysaccharide synthesis]]
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[[Category: Raetz pathway]]
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[[Category: Rossmann-like]]
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[[Category: Transferase]]
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Current revision

Lipid A Disaccharide Synthase (LpxB)-7 solubilizing mutations

PDB ID 5w8s

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