6b45
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6b45 is ON HOLD Authors: Description: Category: Unreleased Structures) |
|||
| (4 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of Type I-F CRISPR crRNA-guided Csy surveillance complex== | |
| + | <SX load='6b45' size='340' side='right' viewer='molstar' caption='[[6b45]], [[Resolution|resolution]] 3.50Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6b45]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa] and [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_UCBPP-PA14 Pseudomonas aeruginosa UCBPP-PA14]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B45 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6B45 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6b45 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b45 OCA], [https://pdbe.org/6b45 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6b45 RCSB], [https://www.ebi.ac.uk/pdbsum/6b45 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6b45 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CSY1_PSEAB CSY1_PSEAB] CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Cas3 and Cascade participate in CRISPR interference, the third stage of CRISPR immunity (Potential). Involved in crRNA production or stability. The Csy ribonucleoprotein complex binds target ssDNA with high affinity but target dsDNA with much lower affinity.<ref>PMID:21398535</ref> <ref>PMID:22522703</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[CRISPR subtype I-F|CRISPR subtype I-F]] | |
| - | + | *[[Endonuclease 3D structures|Endonuclease 3D structures]] | |
| - | [[Category: | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </SX> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Pseudomonas aeruginosa]] | ||
| + | [[Category: Pseudomonas aeruginosa UCBPP-PA14]] | ||
| + | [[Category: Bartesaghi A]] | ||
| + | [[Category: Earl L]] | ||
| + | [[Category: Falconieri V]] | ||
| + | [[Category: Fox T]] | ||
| + | [[Category: Guo TW]] | ||
| + | [[Category: Merk A]] | ||
| + | [[Category: Patel DJ]] | ||
| + | [[Category: Rao P]] | ||
| + | [[Category: Subramaniam S]] | ||
| + | [[Category: Yang H]] | ||
Current revision
Cryo-EM structure of Type I-F CRISPR crRNA-guided Csy surveillance complex
| |||||||||
