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6brx

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'''Unreleased structure'''
 
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The entry 6brx is ON HOLD until Paper Publication
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==Crystal Structure of Human DNA polymerase kappa in complex with DNA containing the major cisplatin lesion==
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<StructureSection load='6brx' size='340' side='right'caption='[[6brx]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6brx]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BRX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BRX FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0KX:2-DEOXY-5-O-[(R)-HYDROXY{[(R)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]AMINO}PHOSPHORYL]CYTIDINE'>0KX</scene>, <scene name='pdbligand=CPT:CISPLATIN'>CPT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6brx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6brx OCA], [https://pdbe.org/6brx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6brx RCSB], [https://www.ebi.ac.uk/pdbsum/6brx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6brx ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/POLK_HUMAN POLK_HUMAN] DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity.<ref>PMID:10620008</ref> <ref>PMID:11024016</ref> <ref>PMID:12145297</ref> <ref>PMID:12444249</ref> <ref>PMID:12952891</ref> <ref>PMID:14630940</ref> <ref>PMID:15533436</ref>
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Authors: Jha, V.K., Ling, H.
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==See Also==
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*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
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Description: Crystal Structure of Human DNA polymerase kappa in complex with DNA containing the major cisplatin lesion
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Jha, V.K]]
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__TOC__
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[[Category: Ling, H]]
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Synthetic construct]]
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[[Category: Jha VK]]
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[[Category: Ling H]]

Current revision

Crystal Structure of Human DNA polymerase kappa in complex with DNA containing the major cisplatin lesion

PDB ID 6brx

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