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6bxr
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Toxoplasma gondii Mitochondrial Association Factor 1 B (MAF1B)== | |
| - | + | <StructureSection load='6bxr' size='340' side='right'caption='[[6bxr]], [[Resolution|resolution]] 1.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6bxr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BXR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BXR FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bxr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bxr OCA], [https://pdbe.org/6bxr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bxr RCSB], [https://www.ebi.ac.uk/pdbsum/6bxr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bxr ProSAT]</span></td></tr> |
| - | [[Category: Parker | + | </table> |
| - | [[Category: | + | == Function == |
| + | [https://www.uniprot.org/uniprot/MAFB1_TOXGO MAFB1_TOXGO] During host cell infection by tachyzoites, required for tethering the parasitophorous vacuole to the host mitochondria (PubMed:26920761, PubMed:24781109, PubMed:28567444, PubMed:33723040, PubMed:35025629, PubMed:29505111). This process, known as host mitochondrial association (HMA), induces the formation of SPOTs (structures positive for outer mitochondrial membrane (OMM)), a cellular response to OMM stress, which leads to the constitutive shedding of OMM vesicles containing proteins such as mitofusins MFN1 and MFN2, which normally restrict parasite growth (PubMed:35025629). Specifically, binds to the host OMM import receptor TOMM70 to interact with SAMM50, a component of host mitochondrial intermembrane space bridging (MIB) complex (PubMed:28567444, PubMed:33723040, PubMed:35025629). By targeting SAMM50, induces the disassembly of the MIB complex, thereby promoting the formation of SPOTs (PubMed:35025629). Inhibits host TOMM70 import activity (PubMed:35025629). Plays a role in the modulation of the host innate immune response to parasite infection (PubMed:24781109, PubMed:30333181).<ref>PMID:24781109</ref> <ref>PMID:26920761</ref> <ref>PMID:28567444</ref> <ref>PMID:29505111</ref> <ref>PMID:30333181</ref> <ref>PMID:33723040</ref> <ref>PMID:35025629</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Toxoplasma gondii]] | ||
| + | [[Category: Boulanger MJ]] | ||
| + | [[Category: Parker ML]] | ||
| + | [[Category: Ramaswamy R]] | ||
Current revision
Crystal structure of Toxoplasma gondii Mitochondrial Association Factor 1 B (MAF1B)
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