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6c78

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==Substrate Binding Induces Conformational Changes In A Class A Beta Lactamase That Primes It For Catalysis==
==Substrate Binding Induces Conformational Changes In A Class A Beta Lactamase That Primes It For Catalysis==
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<StructureSection load='6c78' size='340' side='right' caption='[[6c78]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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<StructureSection load='6c78' size='340' side='right'caption='[[6c78]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6c78]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C78 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C78 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6c78]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C78 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6C78 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DOD:DEUTERATED+WATER'>DOD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Neutron Diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DOD:DEUTERATED+WATER'>DOD</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c78 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c78 OCA], [http://pdbe.org/6c78 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c78 RCSB], [http://www.ebi.ac.uk/pdbsum/6c78 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c78 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6c78 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c78 OCA], [https://pdbe.org/6c78 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6c78 RCSB], [https://www.ebi.ac.uk/pdbsum/6c78 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6c78 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BLT1_ECOLX BLT1_ECOLX]] Has strong cefotaxime-hydrolyzing activity.
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[https://www.uniprot.org/uniprot/BLT1_ECOLX BLT1_ECOLX] Has strong cefotaxime-hydrolyzing activity.
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==See Also==
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*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Beta-lactamase]]
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[[Category: Escherichia coli]]
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[[Category: Coates, L]]
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[[Category: Large Structures]]
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[[Category: Cooper, S J]]
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[[Category: Coates L]]
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[[Category: Ginell, S L]]
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[[Category: Cooper SJ]]
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[[Category: Langan, P S]]
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[[Category: Ginell SL]]
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[[Category: Parks, J M]]
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[[Category: Langan PS]]
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[[Category: Vandavasi, V G]]
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[[Category: Parks JM]]
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[[Category: Weiss, K L]]
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[[Category: Vandavasi VG]]
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[[Category: Hydrolase]]
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[[Category: Weiss KL]]

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Substrate Binding Induces Conformational Changes In A Class A Beta Lactamase That Primes It For Catalysis

PDB ID 6c78

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