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6cbx
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==Crystal structure of human SET and MYND Domain Containing protein 2 with MTF1497== | ==Crystal structure of human SET and MYND Domain Containing protein 2 with MTF1497== | ||
| - | <StructureSection load='6cbx' size='340' side='right' caption='[[6cbx]], [[Resolution|resolution]] 1.94Å' scene=''> | + | <StructureSection load='6cbx' size='340' side='right'caption='[[6cbx]], [[Resolution|resolution]] 1.94Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6cbx]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CBX OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[6cbx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CBX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CBX FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EW1:[3-(4-amino-6-methyl-1H-imidazo[4,5-c]pyridin-1-yl)azetidin-1-yl][1-({1-[(1R)-cyclohept-2-en-1-yl]piperidin-4-yl}methyl)-1H-pyrrol-3-yl]methanone'>EW1</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.94Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EW1:[3-(4-amino-6-methyl-1H-imidazo[4,5-c]pyridin-1-yl)azetidin-1-yl][1-({1-[(1R)-cyclohept-2-en-1-yl]piperidin-4-yl}methyl+)-1H-pyrrol-3-yl]methanone'>EW1</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6cbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cbx OCA], [https://pdbe.org/6cbx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6cbx RCSB], [https://www.ebi.ac.uk/pdbsum/6cbx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6cbx ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/SMYD2_HUMAN SMYD2_HUMAN] Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Has also methyltransferase activity toward non-histone proteins such as p53/TP53 and RB1. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates 'Lys-860' of RB1/RB.<ref>PMID:17108971</ref> <ref>PMID:17805299</ref> <ref>PMID:18065756</ref> <ref>PMID:20870719</ref> |
| + | |||
| + | ==See Also== | ||
| + | *[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Arrowsmith | + | [[Category: Homo sapiens]] |
| - | [[Category: BROWN | + | [[Category: Large Structures]] |
| - | [[Category: Bountra | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Casimiro-Garcia | + | [[Category: BROWN PJ]] |
| - | [[Category: DONG | + | [[Category: Bountra C]] |
| - | [[Category: Edwards | + | [[Category: Casimiro-Garcia A]] |
| - | [[Category: Hutchinson | + | [[Category: DONG A]] |
| - | [[Category: KUMPF | + | [[Category: Edwards AM]] |
| - | [[Category: OWEN | + | [[Category: Hutchinson A]] |
| - | + | [[Category: KUMPF R]] | |
| - | [[Category: Seitova | + | [[Category: OWEN A]] |
| - | [[Category: TATLOCK | + | [[Category: Seitova A]] |
| - | [[Category: TAYLOR | + | [[Category: TATLOCK J]] |
| - | [[Category: WU | + | [[Category: TAYLOR A]] |
| - | [[Category: ZENG | + | [[Category: WU H]] |
| - | + | [[Category: ZENG H]] | |
| - | + | ||
| - | + | ||
Current revision
Crystal structure of human SET and MYND Domain Containing protein 2 with MTF1497
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | BROWN PJ | Bountra C | Casimiro-Garcia A | DONG A | Edwards AM | Hutchinson A | KUMPF R | OWEN A | Seitova A | TATLOCK J | TAYLOR A | WU H | ZENG H
