6cpm

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: '''Unreleased structure''' The entry 6cpm is ON HOLD Authors: Singer, A.U., Teyra, J., Boehmelt, G., Lenter, M., Sicheri, F., Sidhu, S.S. Description: Structure of the USP15 deubiquiti...)
Current revision (14:29, 13 March 2024) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 6cpm is ON HOLD
+
==Structure of the USP15 deubiquitinase domain in complex with a third-generation inhibitory Ubv==
 +
<StructureSection load='6cpm' size='340' side='right'caption='[[6cpm]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[6cpm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CPM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CPM FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.011&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6cpm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cpm OCA], [https://pdbe.org/6cpm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6cpm RCSB], [https://www.ebi.ac.uk/pdbsum/6cpm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6cpm ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/UBP15_HUMAN UBP15_HUMAN] Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling and NF-kappa-B pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes (PubMed:21947082). According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal (PubMed:22344298). Able to mediate deubiquitination of monoubiquitinated substrates as well as 'Lys-48'-linked polyubiquitin chains, protecting them against proteasomal degradation. Acts as an associated component of COP9 signalosome complex (CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP. Protects APC and human papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway.<ref>PMID:16005295</ref> <ref>PMID:17318178</ref> <ref>PMID:19826004</ref> <ref>PMID:19576224</ref> <ref>PMID:19553310</ref> <ref>PMID:21947082</ref> <ref>PMID:22344298</ref>
-
Authors: Singer, A.U., Teyra, J., Boehmelt, G., Lenter, M., Sicheri, F., Sidhu, S.S.
+
==See Also==
-
 
+
*[[Thioesterase 3D structures|Thioesterase 3D structures]]
-
Description: Structure of the USP15 deubiquitinase domain in complex with a third-generation inhibitory Ubv
+
*[[3D structures of ubiquitin|3D structures of ubiquitin]]
-
[[Category: Unreleased Structures]]
+
== References ==
-
[[Category: Sicheri, F]]
+
<references/>
-
[[Category: Lenter, M]]
+
__TOC__
-
[[Category: Teyra, J]]
+
</StructureSection>
-
[[Category: Singer, A.U]]
+
[[Category: Homo sapiens]]
-
[[Category: Sidhu, S.S]]
+
[[Category: Large Structures]]
-
[[Category: Boehmelt, G]]
+
[[Category: Boehmelt G]]
 +
[[Category: Lenter M]]
 +
[[Category: Sicheri F]]
 +
[[Category: Sidhu SS]]
 +
[[Category: Singer AU]]
 +
[[Category: Teyra J]]

Current revision

Structure of the USP15 deubiquitinase domain in complex with a third-generation inhibitory Ubv

PDB ID 6cpm

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6cpm"
Personal tools