This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


6cqb

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (14:29, 13 March 2024) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='6cqb' size='340' side='right'caption='[[6cqb]], [[Resolution|resolution]] 2.91&Aring;' scene=''>
<StructureSection load='6cqb' size='340' side='right'caption='[[6cqb]], [[Resolution|resolution]] 2.91&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[6cqb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Piper_methysticum Piper methysticum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CQB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CQB FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[6cqb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Piper_methysticum Piper methysticum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CQB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CQB FirstGlance]. <br>
-
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CHS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=130404 Piper methysticum])</td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.91&#8491;</td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cqb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cqb OCA], [http://pdbe.org/6cqb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cqb RCSB], [http://www.ebi.ac.uk/pdbsum/6cqb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cqb ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6cqb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cqb OCA], [https://pdbe.org/6cqb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6cqb RCSB], [https://www.ebi.ac.uk/pdbsum/6cqb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6cqb ProSAT]</span></td></tr>
</table>
</table>
-
<div style="background-color:#fffaf0;">
+
== Function ==
-
== Publication Abstract from PubMed ==
+
[https://www.uniprot.org/uniprot/A0A384E133_9MAGN A0A384E133_9MAGN]
-
Kava (Piper methysticum) is an ethnomedicinal shrub native to the Polynesian islands with well-established anxiolytic and analgesic properties. Its main psychoactive principles, kavalactones, form a unique class of polyketides that interact with the human central nervous system through mechanisms distinct from those of conventional psychiatric drugs. However, an unknown biosynthetic machinery and difficulty in chemical synthesis hinder the therapeutic use of kavalactones. In addition, kava also produces flavokavains, which are chalconoids with anticancer properties structurally related to kavalactones. Here, we report de novo elucidation of the key enzymes of the kavalactone and flavokavain biosynthetic network. We present the structural basis for the evolutionary development of a pair of paralogous styrylpyrone synthases that establish the kavalactone scaffold and the catalytic mechanism of a regio- and stereo-specific kavalactone reductase that produces a subset of chiral kavalactones. We further demonstrate the feasibility of engineering styrylpyrone production in heterologous hosts, thus opening a way to develop kavalactone-based non-addictive psychiatric therapeutics through synthetic biology.
+
-
The biosynthetic origin of psychoactive kavalactones in kava.,Pluskal T, Torrens-Spence MP, Fallon TR, De Abreu A, Shi CH, Weng JK Nat Plants. 2019 Jul 22. pii: 10.1038/s41477-019-0474-0. doi:, 10.1038/s41477-019-0474-0. PMID:31332312<ref>PMID:31332312</ref>
+
==See Also==
-
 
+
*[[Chalcone synthase|Chalcone synthase]]
-
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+
-
</div>
+
-
<div class="pdbe-citations 6cqb" style="background-color:#fffaf0;"></div>
+
-
== References ==
+
-
<references/>
+
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Piper methysticum]]
[[Category: Piper methysticum]]
-
[[Category: Pluskal, T]]
+
[[Category: Pluskal T]]
-
[[Category: Weng, J K]]
+
[[Category: Weng JK]]
-
[[Category: Flavokavain biosynthesis]]
+
-
[[Category: Phenylpropanoid pathway]]
+
-
[[Category: Transferase]]
+

Current revision

Crystal Structure of Piper methysticum Chalcone Synthase

PDB ID 6cqb

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6cqb"
Personal tools