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6d6v

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'''Unreleased structure'''
 
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The entry 6d6v is ON HOLD
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==CryoEM structure of Tetrahymena telomerase with telomeric DNA at 4.8 Angstrom resolution==
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<SX load='6d6v' size='340' side='right' viewer='molstar' caption='[[6d6v]], [[Resolution|resolution]] 4.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6d6v]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Tetrahymena_thermophila Tetrahymena thermophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D6V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6D6V FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6d6v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d6v OCA], [https://pdbe.org/6d6v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6d6v RCSB], [https://www.ebi.ac.uk/pdbsum/6d6v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6d6v ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TEB1_TETTS TEB1_TETTS] Single-stranded DNA (ssDNA)-binding protein that mediates the recruitment of telomerase to telomeric DNA (PubMed:19941821, PubMed:20363756, PubMed:25225329, PubMed:22143754). Telomerase is an essential ribonucleoprotein (RNP) enzyme that copies new telomeric repeats onto chromosome ends by repetitively synthesizing the short telomere-repeat sequence 5'-TTGGGG-3' using an RNA template component TER (PubMed:19941821). Acts as part of a replication protein A (RPA)-related subcomplex of the holoenzyme telomerase ribonucleoprotein complex: TEB1 specifically recognizes and binds telomeric ssDNA, thereby mediating the recruitment of the holoenzyme telomerase RNP complex to telomeres (PubMed:19941821, PubMed:25225329, PubMed:27895115). TEB1 is related to RPA1 subunit of the RPA complex but is specific to telomeric DNA, which is not the case of RPA1 (PubMed:25225329).<ref>PMID:19941821</ref> <ref>PMID:20363756</ref> <ref>PMID:22143754</ref> <ref>PMID:25225329</ref> <ref>PMID:27895115</ref>
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Authors:
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==See Also==
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*[[Telomerase 3D structures|Telomerase 3D structures]]
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Description:
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*[[Telomerase-associated protein|Telomerase-associated protein]]
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[[Category: Unreleased Structures]]
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== References ==
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<references/>
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__TOC__
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</SX>
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[[Category: Large Structures]]
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[[Category: Tetrahymena thermophila]]
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[[Category: Basu R]]
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[[Category: Chan H]]
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[[Category: Feigon J]]
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[[Category: Jiang J]]
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[[Category: Susac L]]
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[[Category: Wang Y]]
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[[Category: Zhou ZH]]

Current revision

CryoEM structure of Tetrahymena telomerase with telomeric DNA at 4.8 Angstrom resolution

6d6v, resolution 4.80Å

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