6e7c

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m (Protected "6e7c" [edit=sysop:move=sysop])
Current revision (14:39, 13 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 6e7c is ON HOLD
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==14-pf 3-start GMPCPP-human alpha1B/beta2B microtubules==
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<SX load='6e7c' size='340' side='right' viewer='molstar' caption='[[6e7c]], [[Resolution|resolution]] 3.65&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6e7c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E7C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6E7C FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.65&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=G2P:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>G2P</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6e7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e7c OCA], [https://pdbe.org/6e7c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6e7c RCSB], [https://www.ebi.ac.uk/pdbsum/6e7c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6e7c ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/TBB2B_HUMAN TBB2B_HUMAN] Congenital fibrosis of extraocular muscles;Polymicrogyria due to TUBB2B mutation. The disease is caused by mutations affecting the gene represented in this entry. The disease may be caused by mutations affecting the gene represented in this entry. Defects in TUBB2B may be involved in cerebellar ataxia, mental retardation, and dysequilibrium syndrome (CAMRQ).<ref>PMID:28013290</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/TBB2B_HUMAN TBB2B_HUMAN] Tubulin is the major constituent of microtubules (PubMed:23001566, PubMed:28013290, PubMed:26732629). It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910).<ref>PMID:19465910</ref> <ref>PMID:23001566</ref> <ref>PMID:26732629</ref> <ref>PMID:28013290</ref>
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Authors:
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==See Also==
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*[[Tubulin 3D Structures|Tubulin 3D Structures]]
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Description:
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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__TOC__
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</SX>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Alushin GM]]
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[[Category: Kapoor TM]]
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[[Category: Ti SC]]

Current revision

14-pf 3-start GMPCPP-human alpha1B/beta2B microtubules

6e7c, resolution 3.65Å

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