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6mlc

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PHD6 domain of MLL3 in complex with histone H4

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Retrieved from "http://52.214.119.220/wiki/index.php/6mlc"

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 ==PHD6 domain of MLL3 in complex with histone H4==
-<StructureSection load='6mlc' size='340' side='right' caption='[[6mlc]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
+<StructureSection load='6mlc' size='340' side='right'caption='[[6mlc]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[6mlc]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MLC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MLC FirstGlance]. <br>
+<table><tr><td colspan='2'>[[6mlc]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MLC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MLC FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mlc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mlc OCA], [http://pdbe.org/6mlc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mlc RCSB], [http://www.ebi.ac.uk/pdbsum/6mlc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mlc ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mlc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mlc OCA], [https://pdbe.org/6mlc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mlc RCSB], [https://www.ebi.ac.uk/pdbsum/6mlc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mlc ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/KMT2C_HUMAN KMT2C_HUMAN]] Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. KMT2C/MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder.<ref>PMID:17500065</ref>
+[https://www.uniprot.org/uniprot/KMT2C_HUMAN KMT2C_HUMAN] Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. KMT2C/MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder.<ref>PMID:17500065</ref>
+==See Also==
+*[[Histone 3D structures|Histone 3D structures]]
+*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Histone-lysine N-methyltransferase]]
+[[Category: Homo sapiens]]
-[[Category: Arrowsmith, C H]]
+[[Category: Large Structures]]
-[[Category: Bountra, C]]
+[[Category: Arrowsmith CH]]
-[[Category: Dong, A]]
+[[Category: Bountra C]]
-[[Category: Edwards, A M]]
+[[Category: Dong A]]
-[[Category: Lei, M]]
+[[Category: Edwards AM]]
-[[Category: Liu, Y]]
+[[Category: Lei M]]
-[[Category: Min, J]]
+[[Category: Liu Y]]
-[[Category: Qin, S]]
+[[Category: Min J]]
-[[Category: Structural genomic]]
+[[Category: Qin S]]
-[[Category: Mll3]]
-[[Category: Phd6]]
-[[Category: Sgc]]
-[[Category: Transferase]]

6mlc

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PHD6 domain of MLL3 in complex with histone H4

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