This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
6n5z
From Proteopedia
(Difference between revisions)
m (Protected "6n5z" [edit=sysop:move=sysop]) |
|||
| (2 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the SNX5 PX domain in complex with the Sema4C== | |
| + | <StructureSection load='6n5z' size='340' side='right'caption='[[6n5z]], [[Resolution|resolution]] 2.45Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6n5z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N5Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6N5Z FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6n5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n5z OCA], [https://pdbe.org/6n5z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6n5z RCSB], [https://www.ebi.ac.uk/pdbsum/6n5z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6n5z ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SNX5_HUMAN SNX5_HUMAN] May be involved in several stages of intracellular trafficking. Plays a role in macropinocytosis. Plays a role in the internalization of EGFR after EGF stimulation.<ref>PMID:18854019</ref> <ref>PMID:21048941</ref> [https://www.uniprot.org/uniprot/SEM4C_HUMAN SEM4C_HUMAN] Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration (By similarity). Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade.<ref>PMID:17498836</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Sorting nexin 3D structures|Sorting nexin 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: Collins | + | __TOC__ |
| - | [[Category: Paul | + | </StructureSection> |
| - | [[Category: Weeratunga | + | [[Category: Homo sapiens]] |
| + | [[Category: Large Structures]] | ||
| + | [[Category: Collins B]] | ||
| + | [[Category: Paul B]] | ||
| + | [[Category: Weeratunga S]] | ||
Current revision
Crystal structure of the SNX5 PX domain in complex with the Sema4C
| |||||||||||
