This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
6on4
From Proteopedia
(Difference between revisions)
| (3 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the GntR-type sialoregulator NanR from Escherichia coli, in complex with sialic acid== | |
| - | + | <StructureSection load='6on4' size='340' side='right'caption='[[6on4]], [[Resolution|resolution]] 2.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6on4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ON4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ON4 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P4K:polyethylene+glycol'>P4K</scene>, <scene name='pdbligand=SLB:5-N-ACETYL-BETA-D-NEURAMINIC+ACID'>SLB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6on4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6on4 OCA], [https://pdbe.org/6on4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6on4 RCSB], [https://www.ebi.ac.uk/pdbsum/6on4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6on4 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NANR_ECOLI NANR_ECOLI] Transcriptional repressor that controls expression of the genes required for the catabolism of sialic acids (PubMed:9864311, PubMed:12897000, PubMed:23935044). Represses expression of the nanATEK-yhcH, nanCMS and yjhBC operons. Acts by binding directly to the Nan box, a region of approximately 30 bp covering the promoter region (PubMed:23935044).<ref>PMID:12897000</ref> <ref>PMID:23935044</ref> <ref>PMID:9864311</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Escherichia coli K-12]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Dobson RCJ]] | ||
| + | [[Category: Horne CR]] | ||
| + | [[Category: North RA]] | ||
| + | [[Category: Panjikar S]] | ||
Current revision
Crystal structure of the GntR-type sialoregulator NanR from Escherichia coli, in complex with sialic acid
| |||||||||||
