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7lk1

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'''Unreleased structure'''
 
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The entry 7lk1 is ON HOLD
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==Ornithine Aminotransferase (OAT) with its potent inhibitor - (S)-3-amino-4,4-difluorocyclopent-1-enecarboxylic acid (SS-1-148) - 1 Hour Soaking==
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<StructureSection load='7lk1' size='340' side='right'caption='[[7lk1]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
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Authors: Butrin, A., Shen, S., Liu, D., Silverman, R.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7lk1]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LK1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LK1 FirstGlance]. <br>
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Description: Ornithine Aminotransferase (OAT) with its potent inhibitor -(S)-3-amino-4,4-difluorocyclopent-1-enecarboxylic acid (SS-1-148) -1 Hour Soaking
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.79&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=Y37:(1R,4R)-4-fluoro-3-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]cyclopent-2-ene-1-carboxylic+acid'>Y37</scene></td></tr>
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[[Category: Liu, D]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lk1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lk1 OCA], [https://pdbe.org/7lk1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lk1 RCSB], [https://www.ebi.ac.uk/pdbsum/7lk1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lk1 ProSAT]</span></td></tr>
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[[Category: Shen, S]]
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</table>
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[[Category: Butrin, A]]
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== Disease ==
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[[Category: Silverman, R]]
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[https://www.uniprot.org/uniprot/OAT_HUMAN OAT_HUMAN] Defects in OAT are the cause of hyperornithinemia with gyrate atrophy of choroid and retina (HOGA) [MIM:[https://omim.org/entry/258870 258870]. HOGA is a slowly progressive blinding autosomal recessive disorder.<ref>PMID:3375240</ref> <ref>PMID:2793865</ref> <ref>PMID:1612597</ref> <ref>PMID:1737786</ref> <ref>PMID:7887415</ref> <ref>PMID:7668253</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/OAT_HUMAN OAT_HUMAN]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Butrin A]]
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[[Category: Liu D]]
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[[Category: Shen S]]
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[[Category: Silverman R]]

Current revision

Ornithine Aminotransferase (OAT) with its potent inhibitor - (S)-3-amino-4,4-difluorocyclopent-1-enecarboxylic acid (SS-1-148) - 1 Hour Soaking

PDB ID 7lk1

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