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1a0l

From Proteopedia

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[[Image:1a0l.png|left|200px]]
 
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{{STRUCTURE_1a0l| PDB=1a0l | SCENE= }}
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==HUMAN BETA-TRYPTASE: A RING-LIKE TETRAMER WITH ACTIVE SITES FACING A CENTRAL PORE==
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<StructureSection load='1a0l' size='340' side='right'caption='[[1a0l]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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===HUMAN BETA-TRYPTASE: A RING-LIKE TETRAMER WITH ACTIVE SITES FACING A CENTRAL PORE===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1a0l]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A0L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A0L FirstGlance]. <br>
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{{ABSTRACT_PUBMED_9521329}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=APA:(2S)-3-(4-CARBAMIMIDOYLPHENYL)-2-HYDROXYPROPANOIC+ACID'>APA</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a0l OCA], [https://pdbe.org/1a0l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a0l RCSB], [https://www.ebi.ac.uk/pdbsum/1a0l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a0l ProSAT]</span></td></tr>
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[[1a0l]] is a 4 chain structure of [[Tryptase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A0L OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TRYB2_HUMAN TRYB2_HUMAN] Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Has an immunoprotective role during bacterial infection. Required to efficiently combat K.pneumoniae infection (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a0/1a0l_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a0l ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[Tryptase|Tryptase]]
*[[Tryptase|Tryptase]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:009521329</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Tryptase]]
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[[Category: Large Structures]]
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[[Category: Bergner, A.]]
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[[Category: Bergner A]]
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[[Category: Bode, W.]]
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[[Category: Bode W]]
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[[Category: Fritz, H.]]
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[[Category: Fritz H]]
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[[Category: Huber, R.]]
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[[Category: Huber R]]
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[[Category: Macedo-Ribeiro, S.]]
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[[Category: Macedo-Ribeiro S]]
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[[Category: Matschiner, G.]]
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[[Category: Matschiner G]]
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[[Category: Pereira, P J.B.]]
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[[Category: Pereira PJB]]
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[[Category: Sommerhoff, C P.]]
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[[Category: Sommerhoff CP]]
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[[Category: Allergy]]
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[[Category: Asthma]]
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[[Category: Heparin]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Serine proteinase]]
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[[Category: Tetramer]]
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[[Category: Trypsin-like serine proteinase]]
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Current revision

HUMAN BETA-TRYPTASE: A RING-LIKE TETRAMER WITH ACTIVE SITES FACING A CENTRAL PORE

PDB ID 1a0l

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