This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1a3p

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "1a3p" [edit=sysop:move=sysop])
Current revision (15:20, 13 March 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1a3p.png|left|200px]]
 
-
{{STRUCTURE_1a3p| PDB=1a3p | SCENE= }}
+
==ROLE OF THE 6-20 DISULFIDE BRIDGE IN THE STRUCTURE AND ACTIVITY OF EPIDERMAL GROWTH FACTOR, NMR, 20 STRUCTURES==
-
 
+
<StructureSection load='1a3p' size='340' side='right'caption='[[1a3p]]' scene=''>
-
===ROLE OF THE 6-20 DISULFIDE BRIDGE IN THE STRUCTURE AND ACTIVITY OF EPIDERMAL GROWTH FACTOR, NMR, 20 STRUCTURES===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[1a3p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A3P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A3P FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_10082370}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene></td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a3p OCA], [https://pdbe.org/1a3p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a3p RCSB], [https://www.ebi.ac.uk/pdbsum/1a3p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a3p ProSAT]</span></td></tr>
-
[[1a3p]] is a 1 chain structure of [[Epidermal growth factor]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A3P OCA].
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/EGF_MOUSE EGF_MOUSE] EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity).
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a3/1a3p_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a3p ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
*[[Epidermal growth factor|Epidermal growth factor]]
*[[Epidermal growth factor|Epidermal growth factor]]
-
 
+
__TOC__
-
==Reference==
+
</StructureSection>
-
<ref group="xtra">PMID:010082370</ref><references group="xtra"/>
+
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
-
[[Category: Alewood, D.]]
+
[[Category: Alewood D]]
-
[[Category: Alewood, P.]]
+
[[Category: Alewood P]]
-
[[Category: Barnham, K.]]
+
[[Category: Barnham K]]
-
[[Category: Domagala, T.]]
+
[[Category: Domagala T]]
-
[[Category: Nice, E.]]
+
[[Category: Nice E]]
-
[[Category: Norton, R.]]
+
[[Category: Norton R]]
-
[[Category: Torres, A.]]
+
[[Category: Torres A]]
-
[[Category: Disulfide connectivity]]
+
-
[[Category: Egf-like domain]]
+
-
[[Category: Growth factor]]
+
-
[[Category: Murine epidermal growth factor]]
+

Current revision

ROLE OF THE 6-20 DISULFIDE BRIDGE IN THE STRUCTURE AND ACTIVITY OF EPIDERMAL GROWTH FACTOR, NMR, 20 STRUCTURES

PDB ID 1a3p

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1a3p"
Personal tools