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1abr

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{{Seed}}
 
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[[Image:1abr.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF ABRIN-A==
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The line below this paragraph, containing "STRUCTURE_1abr", creates the "Structure Box" on the page.
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<StructureSection load='1abr' size='340' side='right'caption='[[1abr]], [[Resolution|resolution]] 2.14&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1abr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Abrus_precatorius Abrus precatorius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ABR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ABR FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.14&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=NGZ:2-(ACETYLAMINO)-2-DEOXY-ALPHA-L-GLUCOPYRANOSE'>NGZ</scene></td></tr>
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{{STRUCTURE_1abr| PDB=1abr | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1abr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1abr OCA], [https://pdbe.org/1abr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1abr RCSB], [https://www.ebi.ac.uk/pdbsum/1abr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1abr ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ABRA_ABRPR ABRA_ABRPR] The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA. Abrin-a is more toxic than ricin. The B chain is a galactose-specific lectin that facilitates the binding of abrin to the cell membrane that precedes endocytosis.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ab/1abr_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1abr ConSurf].
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<div style="clear:both"></div>
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===CRYSTAL STRUCTURE OF ABRIN-A===
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==See Also==
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*[[Abrin|Abrin]]
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*[[Abrin 3D structures|Abrin 3D structures]]
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__TOC__
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The line below this paragraph, {{ABSTRACT_PUBMED_7608980}}, adds the Publication Abstract to the page
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 7608980 is the PubMed ID number.
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[[Category: Abrus precatorius]]
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_7608980}}
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[[Category: Chu S-C]]
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[[Category: Liaw Y-C]]
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==About this Structure==
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[[Category: Lin J-Y]]
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1ABR is a [[Protein complex]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ABR OCA].
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[[Category: Lu T-H]]
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[[Category: Tahirov TH]]
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==Reference==
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Crystal structure of abrin-a at 2.14 A., Tahirov TH, Lu TH, Liaw YC, Chen YL, Lin JY, J Mol Biol. 1995 Jul 14;250(3):354-67. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7608980 7608980]
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[[Category: Protein complex]]
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[[Category: Chu, S C.]]
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[[Category: Liaw, Y C.]]
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[[Category: Lin, J Y.]]
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[[Category: Lu, T H.]]
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[[Category: Tahirov, T H.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:32:37 2008''
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Current revision

CRYSTAL STRUCTURE OF ABRIN-A

PDB ID 1abr

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