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1abr
From Proteopedia
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| - | {{Seed}} | ||
| - | [[Image:1abr.png|left|200px]] | ||
| - | + | ==CRYSTAL STRUCTURE OF ABRIN-A== | |
| - | + | <StructureSection load='1abr' size='340' side='right'caption='[[1abr]], [[Resolution|resolution]] 2.14Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1abr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Abrus_precatorius Abrus precatorius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ABR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ABR FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.14Å</td></tr> | |
| - | --> | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=NGZ:2-(ACETYLAMINO)-2-DEOXY-ALPHA-L-GLUCOPYRANOSE'>NGZ</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1abr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1abr OCA], [https://pdbe.org/1abr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1abr RCSB], [https://www.ebi.ac.uk/pdbsum/1abr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1abr ProSAT]</span></td></tr> | |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ABRA_ABRPR ABRA_ABRPR] The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA. Abrin-a is more toxic than ricin. The B chain is a galactose-specific lectin that facilitates the binding of abrin to the cell membrane that precedes endocytosis. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ab/1abr_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1abr ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | == | + | ==See Also== |
| - | + | *[[Abrin|Abrin]] | |
| - | + | *[[Abrin 3D structures|Abrin 3D structures]] | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
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| - | < | + | |
[[Category: Abrus precatorius]] | [[Category: Abrus precatorius]] | ||
| - | [[Category: Chu | + | [[Category: Large Structures]] |
| - | [[Category: Liaw | + | [[Category: Chu S-C]] |
| - | [[Category: Lin | + | [[Category: Liaw Y-C]] |
| - | [[Category: Lu | + | [[Category: Lin J-Y]] |
| - | [[Category: Tahirov | + | [[Category: Lu T-H]] |
| - | + | [[Category: Tahirov TH]] | |
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Current revision
CRYSTAL STRUCTURE OF ABRIN-A
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