This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1ag2

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (15:23, 13 March 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1ag2.png|left|200px]]
 
-
{{STRUCTURE_1ag2| PDB=1ag2 | SCENE= }}
+
==PRION PROTEIN DOMAIN PRP(121-231) FROM MOUSE, NMR, 2 MINIMIZED AVERAGE STRUCTURE==
-
 
+
<StructureSection load='1ag2' size='340' side='right'caption='[[1ag2]]' scene=''>
-
===PRION PROTEIN DOMAIN PRP(121-231) FROM MOUSE, NMR, 2 MINIMIZED AVERAGE STRUCTURE===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[1ag2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AG2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AG2 FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_8700211}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
 
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ag2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ag2 OCA], [https://pdbe.org/1ag2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ag2 RCSB], [https://www.ebi.ac.uk/pdbsum/1ag2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ag2 ProSAT]</span></td></tr>
-
==About this Structure==
+
</table>
-
[[1ag2]] is a 1 chain structure of [[Prion]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AG2 OCA].
+
== Disease ==
-
 
+
[https://www.uniprot.org/uniprot/PRIO_MOUSE PRIO_MOUSE] Note=Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.
-
==See Also==
+
== Function ==
-
*[[Prion|Prion]]
+
[https://www.uniprot.org/uniprot/PRIO_MOUSE PRIO_MOUSE] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains.<ref>PMID:12732622</ref> <ref>PMID:16492732</ref> <ref>PMID:19242475</ref> <ref>PMID:19568430</ref>
-
 
+
== Evolutionary Conservation ==
-
==Reference==
+
[[Image:Consurf_key_small.gif|200px|right]]
-
<ref group="xtra">PMID:008700211</ref><ref group="xtra">PMID:009751723</ref><ref group="xtra">PMID:018654630</ref><ref group="xtra">PMID:019053276</ref><references group="xtra"/>
+
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ag/1ag2_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ag2 ConSurf].
 +
<div style="clear:both"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
-
[[Category: Billeter, M.]]
+
[[Category: Billeter M]]
-
[[Category: Glockshuber, R.]]
+
[[Category: Glockshuber R]]
-
[[Category: Hornemann, S.]]
+
[[Category: Hornemann S]]
-
[[Category: Riek, R.]]
+
[[Category: Riek R]]
-
[[Category: Wider, G.]]
+
[[Category: Wider G]]
-
[[Category: Wuthrich, K.]]
+
[[Category: Wuthrich K]]
-
[[Category: Brain]]
+
-
[[Category: Glycoprotein]]
+
-
[[Category: Gpi-anchor]]
+
-
[[Category: Prion protein]]
+

Current revision

PRION PROTEIN DOMAIN PRP(121-231) FROM MOUSE, NMR, 2 MINIMIZED AVERAGE STRUCTURE

PDB ID 1ag2

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ag2"
Personal tools