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1agq
From Proteopedia
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| - | [[Image:1agq.gif|left|200px]]<br /><applet load="1agq" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1agq, resolution 1.90Å" /> | ||
| - | '''GLIAL CELL-DERIVED NEUROTROPHIC FACTOR FROM RAT'''<br /> | ||
| - | == | + | ==GLIAL CELL-DERIVED NEUROTROPHIC FACTOR FROM RAT== |
| - | + | <StructureSection load='1agq' size='340' side='right'caption='[[1agq]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | == | + | <table><tr><td colspan='2'>[[1agq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AGQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AGQ FirstGlance]. <br> |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1agq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1agq OCA], [https://pdbe.org/1agq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1agq RCSB], [https://www.ebi.ac.uk/pdbsum/1agq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1agq ProSAT]</span></td></tr> | |
| - | == | + | </table> |
| - | X-ray | + | == Function == |
| + | [https://www.uniprot.org/uniprot/GDNF_RAT GDNF_RAT] Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. May also modulate local neuronal effects in distal regions of the motor neuron.<ref>PMID:10828539</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ag/1agq_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1agq ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
| - | + | [[Category: Eigenbrot C]] | |
| - | [[Category: Eigenbrot | + | [[Category: Gerber N]] |
| - | [[Category: Gerber | + | |
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Current revision
GLIAL CELL-DERIVED NEUROTROPHIC FACTOR FROM RAT
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