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1agt

From Proteopedia

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{{Seed}}
 
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[[Image:1agt.png|left|200px]]
 
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==SOLUTION STRUCTURE OF THE POTASSIUM CHANNEL INHIBITOR AGITOXIN 2: CALIPER FOR PROBING CHANNEL GEOMETRY==
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The line below this paragraph, containing "STRUCTURE_1agt", creates the "Structure Box" on the page.
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<StructureSection load='1agt' size='340' side='right'caption='[[1agt]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1agt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leiurus_quinquestriatus_hebraeus Leiurus quinquestriatus hebraeus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AGT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AGT FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1agt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1agt OCA], [https://pdbe.org/1agt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1agt RCSB], [https://www.ebi.ac.uk/pdbsum/1agt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1agt ProSAT]</span></td></tr>
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{{STRUCTURE_1agt| PDB=1agt | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KAX32_LEIHE KAX32_LEIHE] Potent inhibitor of the Shaker potassium channels and its mammalian homologs (Kv1.1/KCNA1, Kv1.3/KCNA3, Kv1.6/KCNA6) (Ki<1 nM for all channels) (PubMed:8204618, PubMed:20007782). Also blocks Kv1.2/KCNA2 (IC(50)=26.8 nM) (PubMed:8204618, PubMed:20007782). It also shows a weak interaction with nicotinic acetylcholine receptors (nAChR), suggesting it may weakly inhibit it (PubMed:31276191).<ref>PMID:20007782</ref> <ref>PMID:8204618</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ag/1agt_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1agt ConSurf].
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<div style="clear:both"></div>
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===SOLUTION STRUCTURE OF THE POTASSIUM CHANNEL INHIBITOR AGITOXIN 2: CALIPER FOR PROBING CHANNEL GEOMETRY===
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==See Also==
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*[[Potassium channel toxin 3D structures|Potassium channel toxin 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_8520473}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 8520473 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_8520473}}
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==About this Structure==
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1AGT is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Leiurus_quinquestriatus_hebraeus Leiurus quinquestriatus hebraeus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AGT OCA].
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==Reference==
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<ref group="xtra">PMID:8520473</ref><references group="xtra"/>
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[[Category: Leiurus quinquestriatus hebraeus]]
[[Category: Leiurus quinquestriatus hebraeus]]
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[[Category: Hidalgo, P.]]
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[[Category: Hidalgo P]]
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[[Category: Kasibhatla, C.]]
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[[Category: Kasibhatla C]]
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[[Category: Krezel, A M.]]
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[[Category: Krezel AM]]
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[[Category: Mackinnon, R.]]
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[[Category: Mackinnon R]]
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[[Category: Wagner, G.]]
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[[Category: Wagner G]]
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[[Category: Potassium channel blocker]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 17:14:12 2009''
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Current revision

SOLUTION STRUCTURE OF THE POTASSIUM CHANNEL INHIBITOR AGITOXIN 2: CALIPER FOR PROBING CHANNEL GEOMETRY

PDB ID 1agt

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