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1ahk

From Proteopedia

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[[Image:1ahk.jpg|left|200px]]
 
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{{Structure
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==DER F 2, THE MAJOR MITE ALLERGEN FROM DERMATOPHAGOIDES FARINAE, NMR, MINIMIZED AVERAGE STRUCTURE==
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|PDB= 1ahk |SIZE=350|CAPTION= <scene name='initialview01'>1ahk</scene>
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<StructureSection load='1ahk' size='340' side='right'caption='[[1ahk]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1ahk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dermatophagoides_farinae Dermatophagoides farinae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AHK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AHK FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ahk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ahk OCA], [https://pdbe.org/1ahk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ahk RCSB], [https://www.ebi.ac.uk/pdbsum/1ahk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ahk ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=[[1ahm|1AHM]]
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ahk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ahk OCA], [http://www.ebi.ac.uk/pdbsum/1ahk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ahk RCSB]</span>
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[https://www.uniprot.org/uniprot/ALL2_DERFA ALL2_DERFA]
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}}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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'''DER F 2, THE MAJOR MITE ALLERGEN FROM DERMATOPHAGOIDES FARINAE, NMR, MINIMIZED AVERAGE STRUCTURE'''
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ah/1ahk_consurf.spt"</scriptWhenChecked>
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==Overview==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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House dust mites cause heavy atopic diseases such as asthma and dermatitis. Among allergens from Dermatophagoides farinae, Der f 2 shows the highest positive rate for atopic patients, but its biological function in mites has been perfectly unknown, as well as the functions of its homologs in human and other animals. We have determined the tertiary structure of Der f 2 by multidimensional nuclear magnetic resonance spectroscopy. Der f 2 was found to be a single-domain protein of immunoglobulin fold, and its structure was the most similar to those of the two regulatory domains of transglutaminase. This fact, binding to the bacterial surface, and other small pieces of information hinted that Der f 2 is related to the innate antibacterial defense system in mites. The immunoglobulin E epitopes are also discussed on the basis of the tertiary structure.
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ahk ConSurf].
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1AHK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Dermatophagoides_farinae Dermatophagoides farinae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AHK OCA].
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<div style="clear:both"></div>
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__TOC__
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==Reference==
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</StructureSection>
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Solution structure of Der f 2, the major mite allergen for atopic diseases., Ichikawa S, Hatanaka H, Yuuki T, Iwamoto N, Kojima S, Nishiyama C, Ogura K, Okumura Y, Inagaki F, J Biol Chem. 1998 Jan 2;273(1):356-60. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9417088 9417088]
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[[Category: Dermatophagoides farinae]]
[[Category: Dermatophagoides farinae]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Hatanaka, H.]]
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[[Category: Hatanaka H]]
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[[Category: Ichikawa, S.]]
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[[Category: Ichikawa S]]
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[[Category: Inagaki, F.]]
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[[Category: Inagaki F]]
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[[Category: Iwamoto, N.]]
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[[Category: Iwamoto N]]
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[[Category: Ogura, K.]]
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[[Category: Ogura K]]
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[[Category: Okumura, Y.]]
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[[Category: Okumura Y]]
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[[Category: Yuuki, T.]]
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[[Category: Yuuki T]]
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[[Category: allergen]]
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[[Category: immunoglobulin fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:40:20 2008''
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Current revision

DER F 2, THE MAJOR MITE ALLERGEN FROM DERMATOPHAGOIDES FARINAE, NMR, MINIMIZED AVERAGE STRUCTURE

PDB ID 1ahk

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