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1alu

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(New page: 200px<br /> <applet load="1alu" size="450" color="white" frame="true" align="right" spinBox="true" caption="1alu, resolution 1.9&Aring;" /> '''HUMAN INTERLEUKIN-6'...)
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[[Image:1alu.gif|left|200px]]<br />
 
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<applet load="1alu" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1alu, resolution 1.9&Aring;" />
 
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'''HUMAN INTERLEUKIN-6'''<br />
 
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==Overview==
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==HUMAN INTERLEUKIN-6==
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Interleukin 6 (IL-6) has many biological activities in vivo, and, deregulation has been implicated in many disease processes. IL-6, a 185, amino acid polypeptide was refolded, purified and crystallized. The, crystals diffracted to beyond 1.9 A and the structure was solved using, single isomorphous replacement. The X-ray structure of IL-6 is composed of, a four helix bundle linked by loops and an additional mini-helix. 157 out, of 185 residues are well defined in the final structure, with 18, N-terminal and 8 A-B loop amino acids displaying no interpretable electron, density. The three-dimensional structure has been used to construct a, model of IL-6 interacting with the IL-6 receptor (alpha-chain) and gp130, (beta-chain) that gives new insight into the process of molecular, recognition and signaling. Based on this model, we predict a fourth, binding site on IL-6, a low affinity IL-6-IL-6 interaction, which may be, necessary for the sequential assembly of a functional hexameric IL-6, receptor complex.
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<StructureSection load='1alu' size='340' side='right'caption='[[1alu]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1alu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ALU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ALU FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1alu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1alu OCA], [https://pdbe.org/1alu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1alu RCSB], [https://www.ebi.ac.uk/pdbsum/1alu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1alu ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/IL6_HUMAN IL6_HUMAN] Genetic variations in IL6 are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[https://omim.org/entry/604302 604302]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis. Note=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men.
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== Function ==
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[https://www.uniprot.org/uniprot/IL6_HUMAN IL6_HUMAN] Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/al/1alu_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1alu ConSurf].
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<div style="clear:both"></div>
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==Disease==
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==See Also==
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Known diseases associated with this structure: Kaposi sarcoma, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147620 147620]], Osteopenia/osteoporosis OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147620 147620]]
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*[[Interleukin 3D structures|Interleukin 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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1ALU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4 and TLA as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1ALU OCA].
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==Reference==
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1.9 A crystal structure of interleukin 6: implications for a novel mode of receptor dimerization and signaling., Somers W, Stahl M, Seehra JS, EMBO J. 1997 Mar 3;16(5):989-97. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9118960 9118960]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Seehra, J.S.]]
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[[Category: Seehra JS]]
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[[Category: Somers, W.S.]]
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[[Category: Somers WS]]
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[[Category: Stahl, M.]]
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[[Category: Stahl M]]
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[[Category: SO4]]
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[[Category: TLA]]
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[[Category: cytokine]]
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[[Category: glycoprotein]]
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[[Category: interleukin]]
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[[Category: receptor]]
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[[Category: signaling]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 15:59:38 2007''
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Current revision

HUMAN INTERLEUKIN-6

PDB ID 1alu

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