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1amn
From Proteopedia
(Difference between revisions)
(New page: 200px<br /> <applet load="1amn" size="450" color="white" frame="true" align="right" spinBox="true" caption="1amn, resolution 2.8Å" /> '''TRANSITION STATE ANA...) |
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| - | [[Image:1amn.gif|left|200px]]<br /> | ||
| - | <applet load="1amn" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1amn, resolution 2.8Å" /> | ||
| - | '''TRANSITION STATE ANALOG: ACETYLCHOLINESTERASE COMPLEXED WITH M-(N,N,N-TRIMETHYLAMMONIO)TRIFLUOROACETOPHENONE'''<br /> | ||
| - | == | + | ==TRANSITION STATE ANALOG: ACETYLCHOLINESTERASE COMPLEXED WITH M-(N,N,N-TRIMETHYLAMMONIO)TRIFLUOROACETOPHENONE== |
| - | + | <StructureSection load='1amn' size='340' side='right'caption='[[1amn]], [[Resolution|resolution]] 2.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | [ | + | <table><tr><td colspan='2'>[[1amn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Tetronarce_californica Tetronarce californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AMN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AMN FirstGlance]. <br> |
| - | [ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAF:M-(N,N,N-TRIMETHYLAMMONIO)-2,2,2-TRIFLUORO-1,1-DIHYDROXYETHYLBENZENE'>NAF</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1amn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1amn OCA], [https://pdbe.org/1amn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1amn RCSB], [https://www.ebi.ac.uk/pdbsum/1amn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1amn ProSAT]</span></td></tr> |
| - | [ | + | </table> |
| - | + | == Function == | |
| - | [[ | + | [https://www.uniprot.org/uniprot/ACES_TETCF ACES_TETCF] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. May be involved in cell-cell interactions. |
| - | + | == Evolutionary Conservation == | |
| - | + | [[Image:Consurf_key_small.gif|200px|right]] | |
| - | + | Check<jmol> | |
| - | + | <jmolCheckbox> | |
| - | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/am/1amn_consurf.spt"</scriptWhenChecked> | |
| - | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |
| - | [ | + | <text>to colour the structure by Evolutionary Conservation</text> |
| - | [[ | + | </jmolCheckbox> |
| - | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1amn ConSurf]. | |
| - | + | <div style="clear:both"></div> | |
| - | + | ||
| - | + | ==See Also== | |
| + | *[[Acetylcholinesterase 3D structures|Acetylcholinesterase 3D structures]] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Tetronarce californica]] | ||
| + | [[Category: Harel M]] | ||
| + | [[Category: Silman I]] | ||
| + | [[Category: Sussman JL]] | ||
Current revision
TRANSITION STATE ANALOG: ACETYLCHOLINESTERASE COMPLEXED WITH M-(N,N,N-TRIMETHYLAMMONIO)TRIFLUOROACETOPHENONE
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