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1aqc

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(New page: 200px<br /> <applet load="1aqc" size="450" color="white" frame="true" align="right" spinBox="true" caption="1aqc, resolution 2.3&Aring;" /> '''X11 PTB DOMAIN-10MER...)
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[[Image:1aqc.gif|left|200px]]<br />
 
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<applet load="1aqc" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1aqc, resolution 2.3&Aring;" />
 
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'''X11 PTB DOMAIN-10MER PEPTIDE COMPLEX'''<br />
 
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==Overview==
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==X11 PTB DOMAIN-10MER PEPTIDE COMPLEX==
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The crystal structure of the phosphotyrosine-binding domain (PTB) of the, X11 protein has been determined, in complex with unphosphorylated peptides, corresponding to a region of beta-amyloid precursor protein (betaAPP) that, is required for receptor internalization. The mode of binding to X11 of, the unphosphorylated peptides, which contain an NPxY motif, resembles that, of phosphorylated peptides bound to the Shc and IRS-1 PTB domains. Eight, peptide residues make specific contacts with the X11 PTB domain, and they, collectively achieve high affinity (KD = 0.32 microM) and specificity., These results suggest that, in contrast to the SH2 domains, the PTB, domains are primarily peptide-binding domains that have, in some cases, acquired specificity for phosphorylated tyrosines.
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<StructureSection load='1aqc' size='340' side='right'caption='[[1aqc]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1aqc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AQC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AQC FirstGlance]. <br>
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1AQC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AQC OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1aqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aqc OCA], [https://pdbe.org/1aqc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1aqc RCSB], [https://www.ebi.ac.uk/pdbsum/1aqc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1aqc ProSAT]</span></td></tr>
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Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain., Zhang Z, Lee CH, Mandiyan V, Borg JP, Margolis B, Schlessinger J, Kuriyan J, EMBO J. 1997 Oct 15;16(20):6141-50. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9321393 9321393]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/APBA1_HUMAN APBA1_HUMAN] Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/aq/1aqc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1aqc ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Kuriyan, J.]]
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[[Category: Kuriyan J]]
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[[Category: Lee, C.H.]]
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[[Category: Lee C-H]]
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[[Category: Zhang, Z.]]
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[[Category: Zhang Z]]
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[[Category: complex (peptide binding module/peptide)]]
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[[Category: peptide binding module]]
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[[Category: ptb domain]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 16:01:08 2007''
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Current revision

X11 PTB DOMAIN-10MER PEPTIDE COMPLEX

PDB ID 1aqc

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