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1aqc

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{{Seed}}
 
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[[Image:1aqc.png|left|200px]]
 
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<!--
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==X11 PTB DOMAIN-10MER PEPTIDE COMPLEX==
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The line below this paragraph, containing "STRUCTURE_1aqc", creates the "Structure Box" on the page.
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<StructureSection load='1aqc' size='340' side='right'caption='[[1aqc]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1aqc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AQC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AQC FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_1aqc| PDB=1aqc | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1aqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aqc OCA], [https://pdbe.org/1aqc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1aqc RCSB], [https://www.ebi.ac.uk/pdbsum/1aqc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1aqc ProSAT]</span></td></tr>
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</table>
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===X11 PTB DOMAIN-10MER PEPTIDE COMPLEX===
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== Function ==
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[https://www.uniprot.org/uniprot/APBA1_HUMAN APBA1_HUMAN] Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP.
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== Evolutionary Conservation ==
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<!--
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_9321393}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 9321393 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/aq/1aqc_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_9321393}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1AQC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AQC OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1aqc ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain., Zhang Z, Lee CH, Mandiyan V, Borg JP, Margolis B, Schlessinger J, Kuriyan J, EMBO J. 1997 Oct 15;16(20):6141-50. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9321393 9321393]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Kuriyan, J.]]
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[[Category: Kuriyan J]]
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[[Category: Lee, C H.]]
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[[Category: Lee C-H]]
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[[Category: Zhang, Z.]]
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[[Category: Zhang Z]]
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[[Category: Peptide binding module]]
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[[Category: Ptb domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:24:25 2008''
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Current revision

X11 PTB DOMAIN-10MER PEPTIDE COMPLEX

PDB ID 1aqc

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