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1asv

From Proteopedia

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[[Image:1asv.png|left|200px]]
 
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{{STRUCTURE_1asv| PDB=1asv | SCENE= }}
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==Avian sarcoma virus integrase catalytic core domain==
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<StructureSection load='1asv' size='340' side='right'caption='[[1asv]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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===Avian sarcoma virus integrase catalytic core domain===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1asv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Avian_sarcoma_virus Avian sarcoma virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ASV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ASV FirstGlance]. <br>
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{{ABSTRACT_PUBMED_7563093}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OCY:HYDROXYETHYLCYSTEINE'>OCY</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1asv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1asv OCA], [https://pdbe.org/1asv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1asv RCSB], [https://www.ebi.ac.uk/pdbsum/1asv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1asv ProSAT]</span></td></tr>
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[[1asv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Avian_sarcoma_virus Avian sarcoma virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ASV OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/POL_RSVSB POL_RSVSB] Capsid protein p27: Self-associates to form the irregular polyhedron core composed of hexamers and pentamers, that encapsulates the genomic RNA-nucleocapsid complex. Assembles as a tube in vitro. Binds to inositol hexakisphosphate (IP6), which allows the assembly of the polyhedral capsid.[UniProtKB:P03322] Plays a role in the oligomerization of the Gag polyprotein and in the stabilization of the immature particle. Essential layering element during tube assembly. Allows the cooperative binging of Gag to the host plasma membrane.[UniProtKB:P03322] Binds strongly to viral nucleic acids and promotes their packaging (By similarity). Plays a role in the maturation-stabilization of the viral dimeric RNA via highly structured zinc-binding motifs (By similarity).[UniProtKB:P03322][UniProtKB:P0C776] The aspartyl protease mediates proteolytic cleavages of Gag and Gag-Pol polyproteins during or shortly after the release of the virion from the plasma membrane. Cleavages take place as an ordered, step-wise cascade to yield mature proteins. This process is called maturation. Displays maximal activity during the budding process just prior to particle release from the cell.[PROSITE-ProRule:PRU00275] Catalyzes viral DNA integration into the host chromosome, by performing a series of DNA cutting and joining reactions (PubMed:9218451). This recombination event is an essential step in the viral replication cycle. Has a strong preference for using the 3'-OH at the viral DNA end as a nucleophile.[UniProtKB:P03354]<ref>PMID:9218451</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/as/1asv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1asv ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Retroviral Integrase|Retroviral Integrase]]
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*[[Retroviral integrase 3D structures|Retroviral integrase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:007563093</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Avian sarcoma virus]]
[[Category: Avian sarcoma virus]]
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[[Category: Alexandratos, J.]]
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[[Category: Large Structures]]
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[[Category: Bujacz, G.]]
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[[Category: Alexandratos J]]
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[[Category: Jaskolski, M.]]
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[[Category: Bujacz G]]
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[[Category: Wlodawer, A.]]
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[[Category: Jaskolski M]]
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[[Category: Dna integration]]
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[[Category: Wlodawer A]]

Current revision

Avian sarcoma virus integrase catalytic core domain

PDB ID 1asv

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