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1atn

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[[Image:1atn.gif|left|200px]]
 
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{{Structure
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==Atomic structure of the actin:DNASE I complex==
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|PDB= 1atn |SIZE=350|CAPTION= <scene name='initialview01'>1atn</scene>, resolution 2.8&Aring;
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<StructureSection load='1atn' size='340' side='right'caption='[[1atn]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CH3:METHYL+GROUP'>CH3</scene> and <scene name='pdbligand=ATP:ADENOSINE-5'-TRIPHOSPHATE'>ATP</scene>
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<table><tr><td colspan='2'>[[1atn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. The June 2001 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Myosin'' by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2001_6 10.2210/rcsb_pdb/mom_2001_6]. The July 2001 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Actin'' by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2001_7 10.2210/rcsb_pdb/mom_2001_7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ATN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ATN FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HIC:4-METHYL-HISTIDINE'>HIC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1atn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1atn OCA], [https://pdbe.org/1atn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1atn RCSB], [https://www.ebi.ac.uk/pdbsum/1atn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1atn ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ACTS_RABIT ACTS_RABIT] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/at/1atn_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1atn ConSurf].
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<div style="clear:both"></div>
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'''ATOMIC STRUCTURE OF THE ACTIN:DNASE I COMPLEX'''
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==See Also==
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*[[Actin 3D structures|Actin 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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The atomic models of the complex between rabbit skeletal muscle actin and bovine pancreatic deoxyribonuclease I both in the ATP and ADP forms have been determined by X-ray analysis at an effective resolution of 2.8 A and 3A, respectively. The two structures are very similar. The actin molecule consists of two domains which can be further subdivided into two subdomains. ADP or ATP is located in the cleft between the domains with a calcium ion bound to the beta- or beta- and gamma-phosphates, respectively. The motif of a five-stranded beta sheet consisting of a beta meander and a right handed beta alpha beta unit appears in each domain suggesting that gene duplication might have occurred. These sheets have the same topology as that found in hexokinase.
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==Disease==
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Known diseases associated with this structure: Myopathy, actin, congenital, with cores OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=102610 102610]], Myopathy, actin, congenital, with excess of thin myofilaments OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=102610 102610]], Myopathy, congenital, with fiber-type disporportion 1 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=102610 102610]], Myopathy, nemaline, 3 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=102610 102610]]
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==About this Structure==
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1ATN is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. The following pages contain interesting information on the relation of 1ATN with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb19_1.html Actin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ATN OCA].
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==Reference==
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Atomic structure of the actin:DNase I complex., Kabsch W, Mannherz HG, Suck D, Pai EF, Holmes KC, Nature. 1990 Sep 6;347(6288):37-44. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/2395459 2395459]
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[[Category: Actin]]
[[Category: Actin]]
[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Large Structures]]
[[Category: Myosin]]
[[Category: Myosin]]
[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
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[[Category: Protein complex]]
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[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Holmes, K C.]]
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[[Category: Holmes KC]]
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[[Category: Kabsch, W.]]
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[[Category: Kabsch W]]
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[[Category: Mannherz, H G.]]
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[[Category: Mannherz HG]]
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[[Category: Pai, E.]]
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[[Category: Pai E]]
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[[Category: Suck, D.]]
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[[Category: Suck D]]
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[[Category: ACE]]
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[[Category: ATP]]
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[[Category: CA]]
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[[Category: CH3]]
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[[Category: endodeoxyribonuclease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:02:05 2008''
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Current revision

Atomic structure of the actin:DNASE I complex

PDB ID 1atn

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