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1au8

From Proteopedia

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[[Image:1au8.gif|left|200px]]
 
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{{Structure
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==HUMAN CATHEPSIN G==
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|PDB= 1au8 |SIZE=350|CAPTION= <scene name='initialview01'>1au8</scene>, resolution 1.9&Aring;
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<StructureSection load='1au8' size='340' side='right'caption='[[1au8]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=KPH:LYSINE+PHOSPHINIC+ACID+GROUP'>KPH</scene>, <scene name='pdbligand=SIN:SUCCINIC+ACID'>SIN</scene>
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<table><tr><td colspan='2'>[[1au8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AU8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AU8 FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_G Cathepsin G], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.20 3.4.21.20] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0H8:N-(3-CARBOXYPROPANOYL)-L-VALYL-N-[(1R)-5-AMINO-1-PHOSPHONOPENTYL]-L-PROLINAMIDE'>0H8</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1au8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1au8 OCA], [https://pdbe.org/1au8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1au8 RCSB], [https://www.ebi.ac.uk/pdbsum/1au8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1au8 ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1au8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1au8 OCA], [http://www.ebi.ac.uk/pdbsum/1au8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1au8 RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/CATG_HUMAN CATG_HUMAN] Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride.<ref>PMID:8194606</ref> <ref>PMID:1861080</ref> <ref>PMID:1937776</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/au/1au8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1au8 ConSurf].
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<div style="clear:both"></div>
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'''HUMAN CATHEPSIN G'''
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==See Also==
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*[[Cathepsin 3D structures|Cathepsin 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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1AU8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AU8 OCA].
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__TOC__
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[[Category: Cathepsin G]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Banbula, A.]]
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[[Category: Banbula A]]
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[[Category: Bode, W.]]
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[[Category: Bode W]]
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[[Category: Medrano, F J.]]
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[[Category: Medrano FJ]]
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[[Category: Potempa, J.]]
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[[Category: Potempa J]]
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[[Category: complex (serine protease/inhibitor)]]
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[[Category: inflammation]]
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[[Category: specificity]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:47:33 2008''
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Current revision

HUMAN CATHEPSIN G

PDB ID 1au8

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