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1b50
From Proteopedia
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| - | {{STRUCTURE_1b50| PDB=1b50 | SCENE= }} | ||
| - | ===NMR STRUCTURE OF HUMAN MIP-1A D26A, 10 STRUCTURES=== | ||
| - | {{ABSTRACT_PUBMED_10347159}} | ||
| - | == | + | ==NMR STRUCTURE OF HUMAN MIP-1A D26A, 10 STRUCTURES== |
| - | [[http://www.uniprot.org/uniprot/CCL3_HUMAN CCL3_HUMAN | + | <StructureSection load='1b50' size='340' side='right'caption='[[1b50]]' scene=''> |
| - | + | == Structural highlights == | |
| - | == | + | <table><tr><td colspan='2'>[[1b50]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B50 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B50 FirstGlance]. <br> |
| - | [[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b50 OCA], [https://pdbe.org/1b50 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b50 RCSB], [https://www.ebi.ac.uk/pdbsum/1b50 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b50 ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | < | + | == Function == |
| + | [https://www.uniprot.org/uniprot/CCL3_HUMAN CCL3_HUMAN] Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).<ref>PMID:8525373</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b5/1b50_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1b50 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Craven CJ]] |
| - | [[Category: | + | [[Category: Dudgeon T]] |
| - | [[Category: | + | [[Category: Higgins LD]] |
| - | [[Category: | + | [[Category: Tan P]] |
| - | [[Category: | + | [[Category: Waltho JP]] |
| - | + | ||
| - | + | ||
Current revision
NMR STRUCTURE OF HUMAN MIP-1A D26A, 10 STRUCTURES
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Categories: Homo sapiens | Large Structures | Craven CJ | Dudgeon T | Higgins LD | Tan P | Waltho JP
