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1b5l

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{{Seed}}
 
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[[Image:1b5l.png|left|200px]]
 
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==OVINE INTERFERON TAU==
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The line below this paragraph, containing "STRUCTURE_1b5l", creates the "Structure Box" on the page.
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<StructureSection load='1b5l' size='340' side='right'caption='[[1b5l]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1b5l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Komagataella_pastoris Komagataella pastoris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B5L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B5L FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1b5l| PDB=1b5l | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b5l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b5l OCA], [https://pdbe.org/1b5l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b5l RCSB], [https://www.ebi.ac.uk/pdbsum/1b5l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b5l ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IFNT1_SHEEP IFNT1_SHEEP] Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-induced increase in oxytocin receptor expression in the endometrium. This results in the suppression of the pulsatile endometrial release of the luteolytic hormone prostaglandin F2-alpha, hindering the regression of the corpus luteum (luteolysis) and therefore a return to ovarian cyclicity. This, and a possible direct effect of IFN-tau on prostaglandin synthesis, leads in turn to continued ovarian progesterone secretion, which stimulates the secretion by the endometrium of the nutrients required for the growth of the conceptus. In summary, displays particularly high antiviral and antiproliferative potency concurrently with particular weak cytotoxicity, high antiluteolytic activity and immunomodulatory properties. In contrast with other IFNs, IFN-tau is not virally inducible.<ref>PMID:8603586</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b5/1b5l_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1b5l ConSurf].
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<div style="clear:both"></div>
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===OVINE INTERFERON TAU===
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==See Also==
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*[[Interferon 3D structures|Interferon 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_9931256}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 9931256 is the PubMed ID number.
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</StructureSection>
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[[Category: Komagataella pastoris]]
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{{ABSTRACT_PUBMED_9931256}}
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[[Category: Large Structures]]
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[[Category: Johnson HJ]]
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==About this Structure==
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[[Category: Radhakrishnan R]]
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1B5L is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pichia_pastoris Pichia pastoris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B5L OCA].
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[[Category: Subramaniam PS]]
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[[Category: Walter LJ]]
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==Reference==
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[[Category: Walter MR]]
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Crystal structure of ovine interferon-tau at 2.1 A resolution., Radhakrishnan R, Walter LJ, Subramaniam PS, Johnson HM, Walter MR, J Mol Biol. 1999 Feb 12;286(1):151-62. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9931256 9931256]
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[[Category: Pichia pastoris]]
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[[Category: Single protein]]
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[[Category: Johnson, H J.]]
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[[Category: Radhakrishnan, R.]]
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[[Category: Subramaniam, P S.]]
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[[Category: Walter, L J.]]
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[[Category: Walter, M R.]]
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[[Category: Cytokine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:19:01 2008''
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Current revision

OVINE INTERFERON TAU

PDB ID 1b5l

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