This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1b5l

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (15:30, 13 March 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1b5l.png|left|200px]]
 
-
<!--
+
==OVINE INTERFERON TAU==
-
The line below this paragraph, containing "STRUCTURE_1b5l", creates the "Structure Box" on the page.
+
<StructureSection load='1b5l' size='340' side='right'caption='[[1b5l]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1b5l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Komagataella_pastoris Komagataella pastoris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B5L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B5L FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
{{STRUCTURE_1b5l| PDB=1b5l | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b5l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b5l OCA], [https://pdbe.org/1b5l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b5l RCSB], [https://www.ebi.ac.uk/pdbsum/1b5l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b5l ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/IFNT1_SHEEP IFNT1_SHEEP] Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-induced increase in oxytocin receptor expression in the endometrium. This results in the suppression of the pulsatile endometrial release of the luteolytic hormone prostaglandin F2-alpha, hindering the regression of the corpus luteum (luteolysis) and therefore a return to ovarian cyclicity. This, and a possible direct effect of IFN-tau on prostaglandin synthesis, leads in turn to continued ovarian progesterone secretion, which stimulates the secretion by the endometrium of the nutrients required for the growth of the conceptus. In summary, displays particularly high antiviral and antiproliferative potency concurrently with particular weak cytotoxicity, high antiluteolytic activity and immunomodulatory properties. In contrast with other IFNs, IFN-tau is not virally inducible.<ref>PMID:8603586</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b5/1b5l_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1b5l ConSurf].
 +
<div style="clear:both"></div>
-
===OVINE INTERFERON TAU===
+
==See Also==
-
 
+
*[[Interferon 3D structures|Interferon 3D structures]]
-
 
+
== References ==
-
<!--
+
<references/>
-
The line below this paragraph, {{ABSTRACT_PUBMED_9931256}}, adds the Publication Abstract to the page
+
__TOC__
-
(as it appears on PubMed at http://www.pubmed.gov), where 9931256 is the PubMed ID number.
+
</StructureSection>
-
-->
+
[[Category: Komagataella pastoris]]
-
{{ABSTRACT_PUBMED_9931256}}
+
[[Category: Large Structures]]
-
 
+
[[Category: Johnson HJ]]
-
==About this Structure==
+
[[Category: Radhakrishnan R]]
-
1B5L is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Pichia_pastoris Pichia pastoris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B5L OCA].
+
[[Category: Subramaniam PS]]
-
 
+
[[Category: Walter LJ]]
-
==Reference==
+
[[Category: Walter MR]]
-
<ref group="xtra">PMID:9931256</ref><references group="xtra"/>
+
-
[[Category: Pichia pastoris]]
+
-
[[Category: Johnson, H J.]]
+
-
[[Category: Radhakrishnan, R.]]
+
-
[[Category: Subramaniam, P S.]]
+
-
[[Category: Walter, L J.]]
+
-
[[Category: Walter, M R.]]
+
-
[[Category: Cytokine]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 14:12:17 2009''
+

Current revision

OVINE INTERFERON TAU

PDB ID 1b5l

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1b5l"
Personal tools