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1b6e

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(New page: 200px<br /> <applet load="1b6e" size="450" color="white" frame="true" align="right" spinBox="true" caption="1b6e, resolution 2.60&Aring;" /> '''HUMAN CD94'''<br />...)
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[[Image:1b6e.gif|left|200px]]<br />
 
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<applet load="1b6e" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1b6e, resolution 2.60&Aring;" />
 
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'''HUMAN CD94'''<br />
 
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==Overview==
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==HUMAN CD94==
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The crystal structure of the extracellular domain of CD94, a component of, the CD94/NKG2 NK cell receptor, has been determined to 2.6 A resolution, revealing a unique variation of the C-type lectin fold. In this variation, the second alpha helix, corresponding to residues 102-112, is replaced by, a loop, the putative carbohydrate-binding site is significantly altered, and the Ca2+-binding site appears nonfunctional. This structure may serve, as a prototype for other NK cell receptors such as Ly-49, NKR-P1, and, CD69. The CD94 dimer observed in the crystal has an extensive hydrophobic, interface that stabilizes the loop conformation of residues 102-112. The, formation of this dimer reveals a putative ligand-binding region for HLA-E, and suggests how NKG2 interacts with CD94.
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<StructureSection load='1b6e' size='340' side='right'caption='[[1b6e]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1b6e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B6E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B6E FirstGlance]. <br>
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1B6E is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1B6E OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b6e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b6e OCA], [https://pdbe.org/1b6e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b6e RCSB], [https://www.ebi.ac.uk/pdbsum/1b6e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b6e ProSAT]</span></td></tr>
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==Reference==
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</table>
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Structure of CD94 reveals a novel C-type lectin fold: implications for the NK cell-associated CD94/NKG2 receptors., Boyington JC, Riaz AN, Patamawenu A, Coligan JE, Brooks AG, Sun PD, Immunity. 1999 Jan;10(1):75-82. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10023772 10023772]
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== Function ==
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[https://www.uniprot.org/uniprot/KLRD1_HUMAN KLRD1_HUMAN] Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b6/1b6e_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1b6e ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Boyington, J.C.]]
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[[Category: Boyington JC]]
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[[Category: Brooks, A.G.]]
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[[Category: Brooks AG]]
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[[Category: Coligan, J.E.]]
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[[Category: Coligan JE]]
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[[Category: Patamawenu, A.]]
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[[Category: Patamawenu A]]
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[[Category: Riaz, A.N.]]
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[[Category: Riaz AN]]
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[[Category: Sun, P.D.]]
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[[Category: Sun PD]]
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[[Category: c-type lectin]]
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[[Category: c-type lectin-like]]
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[[Category: nk cell]]
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[[Category: nkd]]
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[[Category: receptor]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 16:06:34 2007''
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Current revision

HUMAN CD94

PDB ID 1b6e

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