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1b6u

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[[Image:1b6u.jpg|left|200px]]<br /><applet load="1b6u" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1b6u, resolution 3.0&Aring;" />
 
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'''CRYSTAL STRUCTURE OF THE HUMAN KILLER CELL INHIBITORY RECEPTOR (KIR2DL3) SPECIFIC FOR HLA-CW3 RELATED ALLELES'''<br />
 
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==Overview==
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==CRYSTAL STRUCTURE OF THE HUMAN KILLER CELL INHIBITORY RECEPTOR (KIR2DL3) SPECIFIC FOR HLA-CW3 RELATED ALLELES==
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BACKGROUND: T cells and natural killer (NK) cells perform complementary, roles in the cellular immune system. T cells identify infected cells, directly through recognition of antigenic peptides that are displayed at, the target cell surface by the classical major histocompatibility complex, (MHC) class I molecules. NK cells monitor the target cell surface for, malfunction of this display system, lysing potentially infected cells that, might otherwise evade recognition by the T cells. Human killer cell, inhibitory receptors (KIRs) control this process by either inhibiting or, activating the cytotoxic activity of NK cells via specific binding to MHC, class I molecules on the target cell. RESULTS: We report the crystal, structure of the extracellular region of the human p58 KIR (KIR2DL3), which is specific for the human MHC class I molecule HLA-Cw3 and related, alleles. The structure shows the predicted topology of two tandem, immunoglobulin-like domains, but comparison with the previously reported, structure of the related receptor KIR2DL1 reveals an unexpected change of, 23 degrees in the relative orientation of these domains. CONCLUSIONS: The, altered orientation of the immunoglobulin-like domains maintains an, unusually acute interdomain elbow angle, which therefore appears to be a, distinctive feature of the KIRs. The putative MHC class I binding site is, located on the outer surface of the elbow, spanning both domains. The, unexpected observation that this binding site can be modulated by, differences in the relative domain orientations has implications for the, general mechanism of KIR-MHC class I complex formation.
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<StructureSection load='1b6u' size='340' side='right'caption='[[1b6u]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1b6u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B6U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B6U FirstGlance]. <br>
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1B6U is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B6U OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b6u OCA], [https://pdbe.org/1b6u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b6u RCSB], [https://www.ebi.ac.uk/pdbsum/1b6u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b6u ProSAT]</span></td></tr>
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==Reference==
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</table>
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Crystal structure of the human p58 killer cell inhibitory receptor (KIR2DL3) specific for HLA-Cw3-related MHC class I., Maenaka K, Juji T, Stuart DI, Jones EY, Structure. 1999 Apr 15;7(4):391-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10196125 10196125]
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== Function ==
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[https://www.uniprot.org/uniprot/KI2L3_HUMAN KI2L3_HUMAN] Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b6/1b6u_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1b6u ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Jones, E.Y.]]
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[[Category: Jones EY]]
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[[Category: Juji, T.]]
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[[Category: Juji T]]
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[[Category: Maenaka, K.]]
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[[Category: Maenaka K]]
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[[Category: Stuart, D.I.]]
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[[Category: Stuart DI]]
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[[Category: cell surface receptor]]
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[[Category: hla]]
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[[Category: immunoglobulin superfamily]]
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[[Category: killer cell inhibitory receptor]]
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[[Category: major histocompatibility complex class i (mhc class i)]]
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[[Category: natural killer cell]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:31:09 2008''
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Current revision

CRYSTAL STRUCTURE OF THE HUMAN KILLER CELL INHIBITORY RECEPTOR (KIR2DL3) SPECIFIC FOR HLA-CW3 RELATED ALLELES

PDB ID 1b6u

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