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1bcp

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{{Seed}}
 
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[[Image:1bcp.png|left|200px]]
 
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==BINARY COMPLEX OF PERTUSSIS TOXIN AND ATP==
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The line below this paragraph, containing "STRUCTURE_1bcp", creates the "Structure Box" on the page.
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<StructureSection load='1bcp' size='340' side='right'caption='[[1bcp]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1bcp]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Bordetella_pertussis Bordetella pertussis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BCP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BCP FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>
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{{STRUCTURE_1bcp| PDB=1bcp | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bcp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bcp OCA], [https://pdbe.org/1bcp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bcp RCSB], [https://www.ebi.ac.uk/pdbsum/1bcp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bcp ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TOX1_BORPE TOX1_BORPE] S1 is an NAD-dependent ADP-ribosyltransferase, which plays a crucial role in the pathogenesis of B.pertussis causing disruption of normal host cellular regulation. It catalyzes the ADP-ribosylation of a cysteine in the alpha subunit of host heterotrimeric G proteins. In the absence of G proteins it also catalyzes the cleavage of NAD(+) into ADP-ribose and nicotinamide. It irreversibly uncouples the G-alpha GTP-binding proteins from their membrane receptors.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bc/1bcp_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bcp ConSurf].
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<div style="clear:both"></div>
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===BINARY COMPLEX OF PERTUSSIS TOXIN AND ATP===
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==See Also==
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*[[Pertussis toxin|Pertussis toxin]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_8637000}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8637000 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8637000}}
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==About this Structure==
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1BCP is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Bordetella_pertussis Bordetella pertussis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BCP OCA].
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==Reference==
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Crystal structure of the pertussis toxin-ATP complex: a molecular sensor., Hazes B, Boodhoo A, Cockle SA, Read RJ, J Mol Biol. 1996 May 17;258(4):661-71. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8637000 8637000]
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[[Category: Bordetella pertussis]]
[[Category: Bordetella pertussis]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Hazes, B.]]
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[[Category: Hazes B]]
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[[Category: Read, R J.]]
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[[Category: Read RJ]]
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[[Category: Adp-ribosyltransferase]]
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[[Category: Toxin]]
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[[Category: Transferase]]
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[[Category: Whooping cough]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:50:44 2008''
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Current revision

BINARY COMPLEX OF PERTUSSIS TOXIN AND ATP

PDB ID 1bcp

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