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1bj5

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[[Image:1bj5.jpg|left|200px]]<br /><applet load="1bj5" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1bj5, resolution 2.5&Aring;" />
 
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'''HUMAN SERUM ALBUMIN COMPLEXED WITH MYRISTIC ACID'''<br />
 
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==Overview==
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==HUMAN SERUM ALBUMIN COMPLEXED WITH MYRISTIC ACID==
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Human serum albumin (HSA) is the most abundant protein in the circulatory, system. Its principal function is to transport fatty acids, but it is also, capable of binding a great variety of metabolites and drugs. Despite, intensive efforts, the detailed structural basis of fatty acid binding to, HSA has remained elusive. We have now determined the crystal structure of, HSA complexed with five molecules of myristate at 2.5 A resolution. The, fatty acid molecules bind in long, hydrophobic pockets capped by polar, side chains, many of which are basic. These pockets are distributed, asymmetrically throughout the HSA molecule, despite its symmetrical, repeating domain structure.
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<StructureSection load='1bj5' size='340' side='right'caption='[[1bj5]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1bj5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BJ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BJ5 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bj5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bj5 OCA], [https://pdbe.org/1bj5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bj5 RCSB], [https://www.ebi.ac.uk/pdbsum/1bj5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bj5 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[https://omim.org/entry/103600 103600]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bj/1bj5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bj5 ConSurf].
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<div style="clear:both"></div>
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==Disease==
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==See Also==
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Known diseases associated with this structure: Analbuminemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=103600 103600]], Dysalbuminemic hyperthyroxinemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=103600 103600]], Dysalbuminemic hyperzincemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=103600 103600]]
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*[[Albumin 3D structures|Albumin 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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1BJ5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MYR:'>MYR</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BJ5 OCA].
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__TOC__
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</StructureSection>
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==Reference==
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Crystal structure of human serum albumin complexed with fatty acid reveals an asymmetric distribution of binding sites., Curry S, Mandelkow H, Brick P, Franks N, Nat Struct Biol. 1998 Sep;5(9):827-35. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9731778 9731778]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Brick, P.]]
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[[Category: Brick P]]
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[[Category: Curry, S.]]
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[[Category: Curry S]]
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[[Category: Franks, N.]]
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[[Category: Franks N]]
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[[Category: Mandelkow, H.]]
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[[Category: Mandelkow H]]
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[[Category: MYR]]
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[[Category: lipid-binding]]
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[[Category: metal-binding]]
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[[Category: plasma protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:32:23 2008''
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Current revision

HUMAN SERUM ALBUMIN COMPLEXED WITH MYRISTIC ACID

PDB ID 1bj5

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