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1bnb

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[[Image:1bnb.gif|left|200px]]
 
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==SOLUTION STRUCTURE OF BOVINE NEUTROPHIL BETA-DEFENSIN 12: THE PEPTIDE FOLD OF THE BETA-DEFENSINS IS IDENTICAL TO THAT OF THE CLASSICAL DEFENSINS==
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The line below this paragraph, containing "STRUCTURE_1bnb", creates the "Structure Box" on the page.
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<StructureSection load='1bnb' size='340' side='right'caption='[[1bnb]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1bnb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BNB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BNB FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bnb OCA], [https://pdbe.org/1bnb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bnb RCSB], [https://www.ebi.ac.uk/pdbsum/1bnb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bnb ProSAT]</span></td></tr>
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{{STRUCTURE_1bnb| PDB=1bnb | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DFB12_BOVIN DFB12_BOVIN] Has bactericidal activity. Active against E.coli ML35 and S.aureus 502A.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bn/1bnb_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bnb ConSurf].
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<div style="clear:both"></div>
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'''SOLUTION STRUCTURE OF BOVINE NEUTROPHIL BETA-DEFENSIN 12: THE PEPTIDE FOLD OF THE BETA-DEFENSINS IS IDENTICAL TO THAT OF THE CLASSICAL DEFENSINS'''
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==See Also==
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*[[Defensin 3D structures|Defensin 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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The solution structure is reported for bovine neutrophil beta-defensin-12 (BNBD-12), a member of the beta-defensin family of antimicrobial peptides. Structural constraints in the form of proton-proton distances, dihedral angles, and hydrogen bond constraints were derived from two-dimensional, homonuclear magnetic resonance spectroscopy experiments. The three-dimensional structure of BNBD-12 was calculated using distance geometry and restrained molecular dynamics. An ensemble of structures with low NOE constraint violation energies revealed a precisely defined triple-stranded, antiparallel beta-sheet as the structural core of the peptide. The N-terminal beta-strand and three locally well-defined tight turns form a hydrophobic face. Conserved isoleucine and glycine residues form a beta-bulge structure which initiates a beta-hairpin secondary structure motif composed of the second and C-terminal beta-strands. The beta-hairpin contains numerous charged residues and forms the cationic face of BNBD-12. The N-terminal residues were found to be disordered, due to an absence of tertiary NOEs. The triple-stranded beta-sheet, the beta-bulge preceding the hairpin, and the cationic/hydrophobic amphiphilic character are definitive features of all defensin structures determined to date. Further, we predict that the tracheal antimicrobial peptide (TAP) and the recently described gallinacins will have tertiary structures similar to that of BNBD-12.
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==About this Structure==
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1BNB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BNB OCA].
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==Reference==
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Solution structure of bovine neutrophil beta-defensin-12: the peptide fold of the beta-defensins is identical to that of the classical defensins., Zimmermann GR, Legault P, Selsted ME, Pardi A, Biochemistry. 1995 Oct 17;34(41):13663-71. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7577957 7577957]
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Legault, P.]]
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[[Category: Legault P]]
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[[Category: Pardi, A.]]
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[[Category: Pardi A]]
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[[Category: Selsted, M E.]]
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[[Category: Selsted ME]]
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[[Category: Zimmermann, G R.]]
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[[Category: Zimmermann GR]]
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[[Category: Beta-defensin 12]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:43:52 2008''
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Current revision

SOLUTION STRUCTURE OF BOVINE NEUTROPHIL BETA-DEFENSIN 12: THE PEPTIDE FOLD OF THE BETA-DEFENSINS IS IDENTICAL TO THAT OF THE CLASSICAL DEFENSINS

PDB ID 1bnb

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